Gene
mycb
- ID
- ZDB-GENE-040426-780
- Name
- MYC proto-oncogene, bHLH transcription factor b
- Symbol
- mycb Nomenclature History
- Previous Names
-
- cmycb
- C-Myc2 (1)
- zgc:55680
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Acts upstream of or within definitive hemopoiesis and hematopoietic progenitor cell differentiation. Predicted to be located in nucleus. Is expressed in several structures, including caudal vein plexus; intestine; nervous system; presumptive neural retina; and shield. Human ortholog(s) of this gene implicated in several diseases, including angiosarcoma; carcinoma (multiple); demyelinating disease; hematologic cancer (multiple); and prostate cancer (multiple). Orthologous to human MYC (MYC proto-oncogene, bHLH transcription factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 29 figures from 21 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Lin et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Burkitt lymphoma | Alliance | Burkitt lymphoma, somatic | 113970 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003327 | Leucine zipper, Myc |
| Domain | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
| Domain | IPR012682 | Transcription regulator Myc, N-terminal |
| Family | IPR002418 | Transcription regulator Myc |
| Family | IPR050433 | Myc family transcription factors |
| Homologous_superfamily | IPR036638 | Helix-loop-helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Helix-loop-helix DNA-binding domain superfamily | Leucine zipper, Myc | Myc family transcription factors | Myc-type, basic helix-loop-helix (bHLH) domain | Transcription regulator Myc | Transcription regulator Myc, N-terminal |
|---|---|---|---|---|---|---|---|
|
UniProtKB:B2GQB7
|
396 | ||||||
|
UniProtKB:Q7ZVS9
|
396 |
Interactions and Pathways
No data available
Plasmids
No data available