ZFIN ID: ZDB-GENE-020503-1
Gene Name: insulin-like growth factor 1a receptor
Gene Symbol: igf1ra
Previous Names: IGF-IRa (1), wu:fi20b10
Location: Chr: 18   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 11 figures from 8 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  brain, eye, gill, gonad primordium (all 11) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Knockdown reagents: MO1-igf1ra (1), MO2-igf1ra (1)

Allele Type Mutagen Suppliers
la020321Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la020322Tg Transgenic Insertion DNA
    PHENOTYPE
    Data: 4 figures from Schlueter et al., 2006
    Observed in: anterior crista primordium, CaP motoneuron axon, cardiac ventricle, death (all 19) expand
    DISEASE ASSOCIATED WITH igf1ra HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Insulin-like growth factor I, resistance to 270450
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process insulin-like growth factor receptor signaling pathway (more)
    Cellular Component integral component of membrane (more)
    Molecular Function insulin-like growth factor binding (more)
    GO Terms (all 27)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000494 (1)
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR002011 (1)
  • InterPro:IPR003961 (1)
  • InterPro:IPR006211 (1)
  • InterPro:IPR006212 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR009030 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR016246 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020635 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS00239 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50853 (1)
  • Pfam:PF00757 (1)
  • Pfam:PF01030 (1)
  • Pfam:PF07714 (1)
  • EC:2.7.10.1 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA igf1ra-001 (1) 6276
    ncRNA igf1ra-002 (1) 578
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM igf1ra
    Tg(actc1b:dnigf1ra-EGFP), Tg(hsp70l:dnigf1ra-EGFP), Tg(ins:dnigf1ra-EGFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    igf1ra Contained in: [BAC] CH211-200O3 (1) (order this), DKEY-25F3 (1) (order this)
    igf1ra Encodes: [EST] fi20b10 (1)
    [cDNA] MGC:194803 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_152968 (1) 4257 bp
    Genomic GenBank:BX470160 (1) 207501 bp Blast at MegaBLAST
    Polypeptide UniProtKB:B3DK52 (1) 1405 aa
    Sequence Clusters UniGene:104808 (1)
    Sequence Information (all 17)
    OTHER igf1ra GENE PAGES
  • Gene:245701 (1)
  • VEGA:OTTDARG00000013775 (1)
  • Ensembl(Zv9):ENSDARG00000027423 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish igf1ra 18  
    Human IGF1R 15 (15q26.3)
  • OMIM:147370
  • Gene:3480
  • Mouse Igf1r 7 ( 37.27 cM)
  • MGI:96433
  • Gene:16001
  • Orthology Details
    CITATIONS (50)