Gene
igf1ra
- ID
- ZDB-GENE-020503-1
- Name
- insulin-like growth factor 1a receptor
- Symbol
- igf1ra Nomenclature History
- Previous Names
-
- IGF-IRa (1)
- sb:eu1090
- wu:fi20b10
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process and insulin-like growth factor binding activity. Acts upstream of or within several processes, including embryonic organ development; fin regeneration; and insulin-like growth factor receptor signaling pathway. Predicted to be located in membrane. Predicted to be part of insulin receptor complex. Predicted to be active in axon and plasma membrane. Is expressed in several structures, including digestive system; female organism; male organism; musculature system; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; dementia (multiple); kidney cancer (multiple); liver disease (multiple); and neurodegenerative disease (multiple). Orthologous to human IGF1R (insulin like growth factor 1 receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 22 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1090 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Schlueter et al., 2006
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la020321Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la020322Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa9079 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa36639 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36640 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43094 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| umo78 | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-igf1ra | Zebrafish Nomenclature Committee | |
| MO1-igf1ra | N/A | (9) |
| MO2-igf1ra | N/A | (4) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Insulin-like growth factor I, resistance to | 270450 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Conserved_site | IPR002011 | Tyrosine-protein kinase, receptor class II, conserved site |
| Domain | IPR000494 | Receptor L-domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR006211 | Furin-like cysteine-rich domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Family | IPR016246 | Tyrosine-protein kinase, insulin-like receptor |
| Family | IPR050122 | Receptor Tyrosine Kinase |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
| Homologous_superfamily | IPR036941 | Receptor L-domain superfamily |
| Repeat | IPR006212 | Furin-like repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | Fibronectin type III | Fibronectin type III superfamily | Furin-like cysteine-rich domain | Furin-like repeat | Growth factor receptor cysteine-rich domain superfamily | Immunoglobulin-like fold | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor L-domain | Receptor L-domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, insulin-like receptor | Tyrosine-protein kinase, receptor class II, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8N7UZS2 | InterPro | 1405 | |||||||||||||||||
| UniProtKB:A0A8M6YTF7 | InterPro | 1404 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
igf1ra-201
(1)
|
Ensembl | 6,276 nt | ||
| mRNA |
igf1ra-203
(1)
|
Ensembl | 4,302 nt | ||
| ncRNA |
igf1ra-002
(1)
|
Ensembl | 578 nt |
Interactions and Pathways
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(actc1b:dnigf1ra-EGFP) |
|
| 1 | (7) | |
| Tg(hsp70l:dnigf1ra-EGFP) |
|
| 1 | (7) | |
| Tg(ins:dnigf1ra-EGFP) |
|
| 1 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-200O3 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-25F3 | ZFIN Curated Data | |
| Encodes | EST | eu1090 | Thisse et al., 2005 | |
| Encodes | EST | fi20b10 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194803 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_152968 (1) | 4257 nt | ||
| Genomic | GenBank:BX470160 (2) | 207501 nt | ||
| Polypeptide | UniProtKB:A0A8N7UZS2 (1) | 1405 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Hui, J.C.M., Du, P., Webb, S.E., Liu, J.Y.H., Ngan, M.P., Lu, Z., Ng, H.S.H., Yang, L., Khalid, A., Liu, L., Li, Z., Deng, Y., Cui, D., Rudd, J.A. (2024) Imaging analytical technique to assess gastrointestinal motility in vivo using zebrafish larvae with diabetes mellitus-like traits. PLoS One. 19:e0314515e0314515
- Ka, Y., Lee, I., Ji, K. (2024) Thyroid and growth hormone endocrine disruption and mechanisms of homosalate and octisalate using wild-type, thrαa-/-, and dre-miR-499-/- zebrafish embryo/larvae. Ecotoxicology and environmental safety. 286:117170117170
- Rajeswari, J.J., Faught, E., Santos, H., Vijayan, M.M. (2024) Mineralocorticoid receptor activates postnatal adiposity in zebrafish lacking proopiomelanocortin. Journal of Cellular Physiology. 239(12):e31428
- Xie, B., Liang, J., Jiang, J., Zeng, T., Liu, L., Xie, D., Zhu, G., Xiong, L., Zhang, K., Liu, D., Gong, J., Chen, X., Lai, R., Xie, H. (2024) Zebrafish myo7aa affects congenital hearing by regulating Rho-GTPase signaling. Frontiers in molecular neuroscience. 17:14051091405109
- Zang, L., Saitoh, S., Katayama, K., Zhou, W., Nishimura, N., Shimada, Y. (2024) Development of a novel zebrafish model of diabetic nephropathy. Disease models & mechanisms. 17(5):
- Boyd, P., Campbell, L.J., Hyde, D.R. (2023) Clcf1/Crlf1a-mediated signaling is neuroprotective and required for Müller glia proliferation in the light-damaged zebrafish retina. Frontiers in cell and developmental biology. 11:11425861142586
- Lau, E.S., Zhu, B., Sun, M.A., Ngai, S.M., Ge, W. (2023) Proteomic analysis of zebrafish Folliculogenesis identifies YB-1 (Ybx1/ybx1) as a potential gatekeeping molecule controlling early ovarian Folliculogenesis. Biology of reproduction. 109(4):482-497
- Ni, Y., Zhang, Y., Zheng, L., Rong, N., Yang, Y., Gong, P., Yang, Y., Siwu, X., Zhang, C., Zhu, L., Fu, Z. (2023) Bifidobacterium and Lactobacillus improve inflammatory bowel disease in zebrafish of different ages by regulating the intestinal mucosal barrier and microbiota. Life sciences. 324:121699
- Dong, X.R., Wan, S.M., Zhou, J.J., Nie, C.H., Chen, Y.L., Diao, J.H., Gao, Z.X. (2022) Functional Differentiation of BMP7 Genes in Zebrafish: bmp7a for Dorsal-Ventral Pattern and bmp7b for Melanin Synthesis and Eye Development. Frontiers in cell and developmental biology. 10:838721
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