ZFIN ID: ZDB-GENE-000322-1
Gene Name: actin alpha cardiac muscle 1b
Gene Symbol: actc1b    Nomenclature History

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Previous Names: acta1, fa27h01, fb83f06, wu:fa27h01 (1), wu:fb83f06 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have ATP binding activity. Predicted to localize to actin cytoskeleton. Used to study nemaline myopathy. Human ortholog(s) of this gene implicated in atrial heart septal defect 5; dilated cardiomyopathy; dilated cardiomyopathy 1R; and hypertrophic cardiomyopathy 11. Is expressed in several structures, including EVL; mesoderm; musculature system; pericardial region; and trunk. Orthologous to human ACTC1 (actin alpha cardiac muscle 1).
Genome Resources: Alliance (1),  Gene:58114 (1),  Ensembl(GRCz11):ENSDARG00000099197 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la027891Tg Transgenic Insertion Unknown Unknown DNA
sa12367 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45589 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-actc1b
    2
    CRISPR2-actc1b
    2
    MO1-actc1b N/A 2
    MO2-actc1b N/A 2
    DISEASE ASSOCIATED WITH actc1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    atrial heart septal defect 5 Alliance Atrial septal defect 5 612794
    dilated cardiomyopathy 1R Alliance Cardiomyopathy, dilated, 1R 613424
    Left ventricular noncompaction 4 613424
    hypertrophic cardiomyopathy 11 Alliance Cardiomyopathy, hypertrophic, 11 612098
    DISEASE ASSOCIATED WITH actc1b VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    nemaline myopathy WT + MO1-actc1b standard conditions Sztal et al., 2015
    WT + MO2-actc1b standard conditions Sztal et al., 2015
    GENE ONTOLOGY
    Ontology GO Term
    Cellular Component cytoplasm (more)
    Molecular Function ATP binding (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM actc1b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(actb2:Hsa.FUS,actc1b:EGFP) actb2actc1b EGFP Danio rerioHomo sapiens 1 2
    Tg(actc1b-hsp70l:Tomato-chrnd) actc1bhsp70l chrndTomato Danio rerio 1 1
    tg(actc1b:3xflag-hsa.ppargc1a,cryaa:zsgfp) actc1bcryaa FLAGZsGFP Danio rerioHomo sapiens 1 1
    tg(actc1b:3xflag-ppargc1a,cryaa:zsgfp) actc1bcryaa FLAGppargc1aZsGFP Danio rerio 1 1
    tg(actc1b:3xflag-tth.ppargc1a,cryaa:zsgfp) actc1bcryaa FLAGZsGFP Atlantic Bluefin TunaDanio rerio 1 1
    Tg(actc1b:AVI-EGFP-rpl10a) actc1b AVIEGFPrpl10a Danio rerio 1 3
    Tg(actc1b:AVI.aequorin,EGFP) actc1b EGFP Danio rerio 1 5
    Tg(actc1b:Cre) actc1b Cre Danio rerio 1 3
    Tg(actc1b:delta2YFP) actc1b YFP Danio rerio 1 5
    Tg(actc1b:dnigf1ra-EGFP) actc1b EGFPigf1ra Danio rerio 1 4
    Tg(actc1b:DsRed1) actc1b DsRed Danio rerio 1 1
    Tg(actc1b:EBFP2) actc1b EBFP2 Danio rerio 1 6
    Tg(actc1b:EGFP) actc1b EGFP Danio rerio 1 3
    Tg(actc1b:GAL4) actc1b GAL4 Danio rerio 1 6
    Tg(actc1b:GFP) actc1b GFP Danio rerio 1 70
    Tg(actc1b:h2az2a-mCherry) actc1b h2az2amCherry Danio rerio 1 2
    Tg(actc1b:Hpy.CagA-EGFP) actc1b EGFP Danio rerioHelicobacter plylori 1 3
    Tg(actc1b:Hpy.CagA_Y2684S_Y2741S-EGFP) actc1b EGFP Danio rerioHelicobacter plylori 1 3
    Tg(actc1b:Hsa.CLCN1-EGFP) actc1b EGFP Danio rerioHomo sapiens 1 1
    Tg(actc1b:Hsa.CLCN1-IRES-EGFP) actc1b EGFPIRES Danio rerioHomo sapiens 1 1
    Tg(actc1b:Hsa.CLCN1_I553F_H555N-EGFP) actc1b EGFP Danio rerioHomo sapiens 1 1
    Tg(actc1b:Hsa.CLCN1_I553F_H555N-IRES-EGFP) actc1b EGFPIRES Danio rerioHomo sapiens 1 1
    Tg(actc1b:Hsa.CLCN1_L844F-EGFP) actc1b EGFP Danio rerioHomo sapiens 1 1
    Tg(actc1b:Hsa.CLCN1_L844F-IRES-EGFP) actc1b EGFPIRES Danio rerioHomo sapiens 1 1
    Tg(actc1b:Hsa.FLNC-EGFP) actc1b EGFP Danio rerioHomo sapiens 1 1
    Tg(actc1b:Hsa.FUS_R521C,actc1b:EGFP) actb2actc1b EGFP Danio rerioHomo sapiens 1 2
    Tg(actc1b:Hsa.HIST1H2BJ-CFP) actc1b CFP Danio rerioHomo sapiens 1 1
    Tg(actc1b:LIFEACT-EGFP) actc1b EGFPLIFEACT Danio rerio 1 9
    Tg(actc1b:lrp4-GFP) actc1b GFPlrp4 Danio rerio 1 2
    Tg(actc1b:mCherry) actc1b mCherry Danio rerio 2 9
    Tg(actc1b:mCherry-CAAX) actc1b CAAXmCherry Danio rerio 1 11
    Tg(actc1b:Mmu.Rapsn-EGFP) actc1b EGFP Danio rerioMus musculus 1 3
    tg(actc1b:nls-mcherry) actc1b mCherryNLS Danio rerio 1 2
    Tg(actc1b:plod3-mKate2) actc1b mKate2plod3 Danio rerio 1 2
    Tg(actc1b:rapsn-CFP) actc1b CFPrapsn Danio rerio 1 3
    Tg(actc1b:RFP) actc1b RFP Danio rerio 1 12
    Tg(actc1b:Rno.Chrna7-YFP) actc1b YFP Danio rerioRattus norvegicus 1 2
    tg(actc1b:rtta,tetre:rtn4a,dsred,myl7:egfp) actc1bmyl7TETRE DsRedEGFPrtn4aRTTA Danio rerio 1 2
    Tg(actc1b:Sha.Cp) actc1b Danio rerio 3 2
    Tg(actc1b:Sha.Cp_E63S) actc1b Danio rerio 1 2
    tg(actc1b:sirt5-zsgfp,cryaa:zsgfp) actc1bcryaa sirt5ZsGFP Danio rerio 1 1
    Tg(actc1b:stac3-EGFP) actc1b EGFPstac3 Danio rerio 1 1
    tg(actc1b:tfeb-zsgfp) actc1b tfebZsGFP Danio rerio 1 2
    tg(actc1b:tomm20a-zsgfp,cryaa:tdtomato) actc1bcryaa Tomatotomm20aZsGFP Danio rerio 1 2
    Tg2(actc1b:Cre) actc1b Cre Danio rerio 1 1
    Tg2(actc1b:stac3-EGFP) actc1b EGFPstac3 Danio rerio 1 1
    MARKER RELATIONSHIPS
    actc1b Encodes: [EST] eu184 (1), fa27h01 (1), fb83f06 (1), fc17f05 (1) (order this)
    [cDNA] MGC:55618 (1), MGC:77653 (1)
    actc1b Has Artifact: [cDNA] MGC:172132 (1), MGC:174190 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131591 (1) 1284 nt
    Genomic GenBank:CABZ01089194 (1) 30349 nt
    Select Tool
    Polypeptide UniProtKB:Q7ZU23 (1) 377 aa
    Sequence Information (all 22)
    ORTHOLOGY for actc1b ( Chr: 17 )
    CITATIONS (96)