Gene
naca
- ID
- ZDB-GENE-020423-4
- Name
- nascent polypeptide associated complex subunit alpha
- Symbol
- naca Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable unfolded protein binding activity. Acts upstream of or within definitive hemopoiesis and myofibril assembly. Located in cytoplasm and nucleus. Is expressed in cardiac muscle; caudal hematopoietic tissue; hematopoietic system; skeletal muscle; and somite. Orthologous to several human genes including NACA2 (nascent polypeptide associated complex subunit alpha 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi5Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| la010752Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la022503Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| t30953 | Allele with one point mutation | Exon 4 | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-naca | N/A | Li et al., 2009 |
| MO2-naca | N/A | Li et al., 2009 |
| MO3-naca | N/A | Murayama et al., 2015 |
| MO4-naca | N/A | Murayama et al., 2015 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002715 | Nascent polypeptide-associated complex NAC domain |
| Domain | IPR044034 | Nascent polypeptide-associated complex subunit alpha-like, UBA domain |
| Family | IPR016641 | Nascent polypeptide-associated complex subunit alpha-like |
| Homologous_superfamily | IPR038187 | NAC A/B domain superfamily |
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Domain Details Per Protein
| Protein | Length | NAC A/B domain superfamily | Nascent polypeptide-associated complex NAC domain | Nascent polypeptide-associated complex subunit alpha-like | Nascent polypeptide-associated complex subunit alpha-like, UBA domain |
|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IQN8
|
1030 | ||||
|
UniProtKB:B2GPE2
|
215 | ||||
|
UniProtKB:Q8JIU7
|
215 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-248G18 | ZFIN Curated Data | |
| Encodes | EST | tdsubc_2b5 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:153880 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191487 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001193352 (1) | 3323 nt | ||
| Genomic | GenBank:CR381647 (1) | 179855 nt | ||
| Polypeptide | UniProtKB:A0A0R4IQN8 (1) | 1030 aa |
- Fernandez, J.P., Moreno-Mateos, M.A., Gohr, A., Miao, L., Chan, S.H., Irimia, M., Giraldez, A.J. (2018) RES complex is associated with intron definition and required for zebrafish early embryogenesis. PLoS Genetics. 14:e1007473
- Yan, Y., He, F., Li, Z., Xu, R., Li, T., Su, J., Liu, X., Zhao, M., Wu, W. (2018) The important role of apolipoprotein A-II in ezetimibe driven reduction of high cholesterol diet-induced atherosclerosis. Atherosclerosis. 280:99-108
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Murayama, E., Sarris, M., Redd, M., Le Guyader, D., Vivier, C., Horsley, W., Trede, N., Herbomel, P. (2015) NACA deficiency reveals the crucial role of somite-derived stromal cells in haematopoietic niche formation. Nature communications. 6:8375
- Tseng, L.C., Zhang, C., Cheng, C.M., Xu, H., Hsu, C.H., Jiang, Y.J. (2014) New classes of mind bomb-interacting proteins identified from yeast two-hybrid screens. PLoS One. 9:e93394
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Ozbudak, E.M., Tassy, O., and Pourquié, O. (2010) Spatiotemporal compartmentalization of key physiological processes during muscle precursor differentiation. Proceedings of the National Academy of Sciences of the United States of America. 107(9):4224-4229
- Li, H., Randall, W.R., and Du, S.J. (2009) skNAC (skeletal Naca), a muscle-specific isoform of Naca (nascent polypeptide-associated complex alpha), is required for myofibril organization. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 23(6):1988-2000
- Lemeer, S., Pinkse, M.W., Mohammed, S., van Breukelen, B., den Hertog, J., Slijper, M., and Heck, A.J. (2008) Online Automated in Vivo Zebrafish Phosphoproteomics: From Large-Scale Analysis Down to a Single Embryo. Journal of Proteome Research. 7(4):1555-1564
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