ZFIN ID: ZDB-PERS-031117-1
Levraud, Jean-Pierre
Email: jean-pierre.levraud@pasteur.fr
URL: https://neuropsi.cnrs.fr/annuaire/jean-pierre-levraud/
Affiliation: Team Neuro-Infection and Immunity
Address: NeuroPSI - Paris-Saclay Institute of Neuroscience Team Neuro-Infection and Immunity Campus CEA Saclay 151 route de la Rotonde 91400 Saclay France
Country: France
Phone: (+33) 1 69 82 42 95
ORCID ID: 0000-0001-6775-2416


Banerjee, P., Joly, P., Jouneau, L., Jaszczyszyn, Y., Bourge, M., Affaticati, P., Levraud, J.P., Boudinot, P., Joly, J.S. (2022) Molecular and Cellular Analysis of the Repair of Zebrafish Optic Tectum Meninges Following Laser Injury. Cells. 11(13)
Kraus, A., Huertas, M., Ellis, L., Boudinot, P., Levraud, J.P., Salinas, I. (2022) Intranasal delivery of SARS-CoV-2 Spike protein is sufficient to cause olfactory damage, inflammation and olfactory dysfunction in zebrafish. Brain, behavior, and immunity. 102:341-359
Laghi, V., Rezelj, V., Boucontet, L., Frétaud, M., Da Costa, B., Boudinot, P., Salinas, I., Lutfalla, G., Vignuzzi, M., Levraud, J.P. (2022) Exploring Zebrafish Larvae as a COVID-19 Model: Probable Abortive SARS-CoV-2 Replication in the Swim Bladder. Frontiers in cellular and infection microbiology. 12:790851
Rutherford, H.A., Clarke, A., Chambers, E.V., Petts, J.J., Carson, E.G., Isles, H.M., Duque-Jaramillo, A., Renshaw, S.A., Levraud, J.P., Hamilton, N. (2022) A zebrafish reporter line reveals immune and neuronal expression of endogenous retrovirus. Disease models & mechanisms. 15(4):
Rességuier, J., Levraud, J.P., Dal, N.K., Fenaroli, F., Primard, C., Wohlmann, J., Carron, G., Griffiths, G.W., Le Guellec, D., Verrier, B. (2021) Biodistribution of surfactant-free poly(lactic-acid) nanoparticles and uptake by endothelial cells and phagocytes in zebrafish: Evidence for endothelium to macrophage transfer. Journal of controlled release : official journal of the Controlled Release Society. 331:228-245
Colucci-Guyon, E., Rifflet, A., Saint-Auret, S., da Costa, A., Boucontet, L., Laval, T., Prehaud, C., Blanchard, N., Levraud, J.P., Boneca, I.G., Demangel, C., Guenin-Macé, L. (2020) Spatiotemporal analysis of mycolactone distribution in vivo reveals partial diffusion in the central nervous system. PLoS neglected tropical diseases. 14:e0008878
Widziolek, M., Janik, K., Mojzesz, M., Pooranachandran, N., Adamek, M., Pecio, A., Surachetpong, W., Levraud, J.P., Boudinot, P., Chadzinska, M., Rakus, K. (2020) Type I interferon-dependent response of zebrafish larvae during tilapia lake virus (TiLV) infection. Developmental and comparative immunology. 116:103936
Stressmann, F.A., Bernal-Bayard, J., Perez-Pascual, D., Audrain, B., Rendueles, O., Briolat, V., Bruchmann, S., Volant, S., Ghozlane, A., Häussler, S., Duchaud, E., Levraud, J.P., Ghigo, J.M. (2020) Mining zebrafish microbiota reveals key community-level resistance against fish pathogen infection. The ISME Journal. 15(3):702-719
Maarifi, G., Smith, N., Maillet, S., Moncorgé, O., Chamontin, C., Edouard, J., Sohm, F., Blanchet, F.P., Herbeuval, J.P., Lutfalla, G., Levraud, J.P., Arhel, N.J., Nisole, S. (2019) TRIM8 is required for virus-induced IFN response in human plasmacytoid dendritic cells. Science advances. 5:eaax3511
Levraud, J.P., Herbomel, P. (2019) Resident Macrophage Lookalikes of Unexpected Origin. Developmental Cell. 49:501-502
Langevin, C., Levraud, J.P., Boudinot, P. (2018) Fish antiviral tripartite motif (TRIM) proteins. Fish & shellfish immunology. 86:724-733
Hernández, P.P., Strzelecka, P.M., Athanasiadis, E.I., Hall, D., Robalo, A.F., Collins, C.M., Boudinot, P., Levraud, J.P., Cvejic, A. (2018) Single-cell transcriptional analysis reveals ILC-like cells in zebrafish. Science immunology. 3(29):
Phan, Q.T., Sipka, T., Gonzalez, C., Levraud, J.P., Lutfalla, G., Nguyen-Chi, M. (2018) Neutrophils use superoxide to control bacterial infection at a distance. PLoS pathogens. 14:e1007157
Boucontet, L., Passoni, G., Thiry, V., Maggi, L., Herbomel, P., Levraud, J.P., Colucci-Guyon, E. (2018) A Model of Superinfection of Virus-Infected Zebrafish Larvae: Increased Susceptibility to Bacteria Associated With Neutrophil Death. Frontiers in immunology. 9:1084
Passoni, G., Langevin, C., Palha, N., Mounce, B.C., Briolat, V., Affaticati, P., De Job, E., Joly, J.S., Vignuzzi, M., Saleh, M.C., Herbomel, P., Boudinot, P., Levraud, J.P. (2017) Imaging of viral neuroinvasion in the zebrafish reveals that Sindbis and chikungunya viruses favour different entry routes. Disease models & mechanisms. 10(7):847-857
Langevin, C., Aleksejeva, E., Houel, A., Briolat, V., Torhy, C., Lunazzi, A., Levraud, J.P., Boudinot, P. (2017) FTR83, a Member of the Large Fish-Specific finTRIM Family, Triggers IFN Pathway and Counters Viral Infection. Frontiers in immunology. 8:617
Rességuier, J., Delaune, E., Coolen, A.L., Levraud, J.P., Boudinot, P., Le Guellec, D., Verrier, B. (2017) Specific and Efficient Uptake of Surfactant-Free Poly(Lactic Acid) Nanovaccine Vehicles by Mucosal Dendritic Cells in Adult Zebrafish after Bath Immersion. Frontiers in immunology. 8:190
Aleksejeva, E., Houel, A., Briolat, V., Levraud, J.P., Langevin, C., Boudinot, P. (2016) Zebrafish Plzf transcription factors enhance early type I IFN response induced by two non-enveloped RNA viruses. Developmental and comparative immunology. 57:48-56
Nguyen Chi, M., Laplace-Builhe, B., Travnickova, J., Luz-Crawford, P., Tejedor, G., Phan, Q.T., Duroux-Richard, I., Levraud, J.P., Kissa, K., Lutfalla, G., Jorgensen, C., Djouad, F. (2015) Identification of polarized macrophage subsets in zebrafish. eLIFE. 4:e07288
Kasher, P.R., Jenkinson, E.M., Briolat, V., Gent, D., Morrissey, C., Zeef, L.A., Rice, G.I., Levraud, J.P., Crow, Y.J. (2015) Characterization of samhd1 Morphant Zebrafish Recapitulates Features of the Human Type I Interferonopathy Aicardi-Goutières Syndrome. Journal of immunology (Baltimore, Md. : 1950). 194(6):2819-25
Levraud, J.P., Palha, N., Langevin, C., Boudinot, P. (2014) Through the looking glass: witnessing host-virus interplay in zebrafish. Trends in microbiology. 22(9):490-497
Nguyen-Chi, M., Phan, Q.T., Gonzalez, C., Dubremetz, J.F., Levraud, J.P., Lutfalla, G. (2014) Transient infection of the zebrafish notochord with E. coli induces chronic inflammation. Disease models & mechanisms. 7:871-882
Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41
Langevin, C., Aleksejeva, E., Passoni, G., Palha, N., Levraud, J.P., and Boudinot, P. (2013) The Antiviral Innate Immune Response in Fish: Evolution and Conservation of the IFN System. Journal of molecular biology. 425(24):4904-20
Langevin, C., van der Aa, L.M., Houel, A., Torhy, C., Briolat, V., Lunazzi, A., Harmache, A., Bremont, M., Levraud, J.P., and Boudinot, P. (2013) Zebrafish ISG15 exerts a strong anti-viral activity against RNA and DNA viruses and regulates the interferon response. Journal of virology. 87(18):10025-36
Mostowy, S., Boucontet, L., Mazon Moya, M.J., Sirianni, A., Boudinot, P., Hollinshead, M., Cossart, P., Herbomel, P., Levraud, J.P., and Colucci-Guyon, E. (2013) The Zebrafish as a New Model for the In Vivo Study of Shigella flexneri Interaction with Phagocytes and Bacterial Autophagy. PLoS pathogens. 9(9):e1003588
Palha, N., Guivel-Benhassine, F., Briolat, V., Lutfalla, G., Sourisseau, M., Ellett, F., Wang, C.H., Lieschke, G.J., Herbomel, P., Schwartz, O., and Levraud, J.P. (2013) Real-time whole-body visualization of chikungunya virus infection and host interferon response in zebrafish. PLoS pathogens. 9(9):e1003619
van der Aa, L.M., Chadzinska, M., Derks, W., Scheer, M., Levraud, J.P., Boudinot, P., and Lidy Verburg-van Kemenade, B.M. (2012) Diversification of IFNγ-inducible CXCb chemokines in cyprinid fish. Developmental and comparative immunology. 38(2):243-253
Rendueles, O., Ferrières, L., Frétaud, M., Bégaud, E., Herbomel, P., Levraud, J.P., and Ghigo, J.M. (2012) A new zebrafish model of Oro-intestinal pathogen colonization reveals a key role for adhesion in protection by probiotic bacteria. PLoS pathogens. 8(7):e1002815
Hamming, O.J., Lutfalla, G., Levraud, J.P., and Hartmann, R. (2011) Crystal structure of zebrafish Interferons 1 and 2 reveals a conservation of type I Interferon structure in vertebrates. Journal of virology. 85(16):8181-7
Ludwig, M., Palha, N., Torhy, C., Briolat, V., Colucci-Guyon, E., Brémont, M., Herbomel, P., Boudinot, P., and Levraud, J.P. (2011) Whole-Body Analysis of a Viral Infection: Vascular Endothelium is a Primary Target of Infectious Hematopoietic Necrosis Virus in Zebrafish Larvae. PLoS pathogens. 7(2):e1001269
Boudinot, P., van der Aa, L.M., Jouneau, L., Du Pasquier, L., Pontarotti, P., Briolat, V., Benmansour, A., and Levraud, J.P. (2011) Origin and Evolution of TRIM Proteins: New Insights from the Complete TRIM Repertoire of Zebrafish and Pufferfish. PLoS One. 6(7):e22022
Aggad, D., Stein, C., Sieger, D., Mazel, M., Boudinot, P., Herbomel, P., Levraud, J.P., Lutfalla, G., and Leptin, M. (2010) In Vivo Analysis of Ifn-γ1 and Ifn-γ2 Signaling in Zebrafish. Journal of immunology (Baltimore, Md. : 1950). 185(11):6774-6782
Aggad, D., Mazel, M., Boudinot, P., Mogensen, K.E., Hamming, O.J., Hartmann, R., Kotenko, S., Herbomel, P., Lutfalla, G., and Levraud, J.P. (2009) The two groups of zebrafish virus-induced interferons signal via distinct receptors with specific and shared chains. Journal of immunology (Baltimore, Md. : 1950). 183(6):3924-3931
Levraud, J.P., Disson, O., Kissa, K., Bonne, I., Cossart, P., Herbomel, P., and Lecuit, M. (2009) Real-time observation of Listeria-phagocyte interactions in the living zebrafish larva. Infection and Immunity. 77(9):3651-3660
van der Aa, L.M., Levraud, J.P., Yahmi, M., Lauret, E., Briolat, V., Herbomel, P., Benmansour, A., and Boudinot, P. (2009) A large new subset of TRIM genes highly diversified by duplication and positive selection in teleost fish. BMC Biology. 7:7
Levraud, J.P., Colucci-Guyon, E., Redd, M.J., Lutfalla, G., and Herbomel, P. (2008) In Vivo Analysis of Zebrafish Innate Immunity. Methods in molecular biology (Clifton, N.J.). 415:337-363
Levraud, J.P., Boudinot, P., Colin, I., Benmansour, A., Peyriéras, N., Herbomel, P., and Lutfalla, G. (2007) Identification of the Zebrafish IFN Receptor: Implications for the Origin of the Vertebrate IFN System. Journal of immunology (Baltimore, Md. : 1950). 178(7):4385-4394
Herbomel, P., and Levraud, J.P. (2005) Imaging Early Macrophage Differentiation, Migration, and Behaviors in Live Zebrafish Embryos. Methods in molecular medicine. 105:199-214