PUBLICATION
The Antiviral Innate Immune Response in Fish: Evolution and Conservation of the IFN System
- Authors
- Langevin, C., Aleksejeva, E., Passoni, G., Palha, N., Levraud, J.P., and Boudinot, P.
- ID
- ZDB-PUB-131029-14
- Date
- 2013
- Source
- Journal of molecular biology 425(24): 4904-20 (Review)
- Registered Authors
- Levraud, Jean-Pierre
- Keywords
- none
- MeSH Terms
-
- Animals
- Biological Evolution
- Fish Diseases/immunology*
- Fish Diseases/virology
- Fish Proteins/genetics
- Fish Proteins/metabolism
- Fishes
- Host-Pathogen Interactions/immunology
- Humans
- Immunity, Innate/immunology*
- Interferons/genetics
- Interferons/metabolism*
- Mammals/genetics
- Mammals/immunology
- Mammals/metabolism
- Organ Specificity
- Receptors, Interferon/genetics
- Receptors, Interferon/metabolism
- Signal Transduction/immunology
- Virus Diseases/immunology*
- Virus Diseases/virology
- PubMed
- 24075867 Full text @ J. Mol. Biol.
Citation
Langevin, C., Aleksejeva, E., Passoni, G., Palha, N., Levraud, J.P., and Boudinot, P. (2013) The Antiviral Innate Immune Response in Fish: Evolution and Conservation of the IFN System. Journal of molecular biology. 425(24):4904-20.
Abstract
Innate immunity constitutes the first line of the host defense after pathogen invasion. Viruses trigger the expression of interferons (IFNs). These master antiviral cytokines induce in turn a large number of interferon-stimulated genes, which possess diverse effector and regulatory functions. The IFN system is conserved in all tetrapods as well as in fishes, but not in tunicates or in the lancelet, suggesting that it originated in early vertebrates. Viral diseases are an important concern of fish aquaculture, which is why fish viruses and antiviral responses have been studied mostly in species of commercial value, such as salmonids. More recently, there has been an interest in the use of more tractable model fish species, notably the zebrafish. Progress in genomics now makes it possible to get a relatively complete image of the genes involved in innate antiviral responses in fish. In this review, by comparing the IFN system between teleosts and mammals, we will focus on its evolution in vertebrates.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping