ZFIN ID: ZDB-PUB-190522-7
Resident Macrophage Lookalikes of Unexpected Origin
Levraud, J.P., Herbomel, P.
Date: 2019
Source: Developmental Cell   49: 501-502 (Other)
Registered Authors: Herbomel, Philippe, Levraud, Jean-Pierre
Keywords: none
MeSH Terms:
  • Animals
  • Ectoderm
  • Epidermis
  • Langerhans Cells*
  • Macrophages
  • Zebrafish*
PubMed: 31112695 Full text @ Dev. Cell
ABSTRACT
In this issue of Developmental Cell, Lin et al. (2019) identify in zebrafish skin macrophage-like cells that sample the environment through transepithelial protrusions and import antigen from the water for traditional tissue-resident macrophages. Remarkably, these "metaphocytes" originate from the epidermis, challenging current assumptions about the lineage of tissue-resident macrophages.
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