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Gene

apoa1a

ID
ZDB-GENE-990415-14
Name
apolipoprotein A-Ia
Symbol
apoa1a Nomenclature History
Previous Names
  • apoa1 (1)
  • apoa
  • cb49 (1)
  • etID309895.5 (1)
  • etID32161.5 (1)
  • wu:fb33f01 (1)
  • zgc:103718
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to enable several functions, including cholesterol binding activity; cholesterol transfer activity; and high-density lipoprotein particle binding activity. Predicted to be involved in several processes, including lipid homeostasis; lipid transport; and plasma lipoprotein particle organization. Predicted to act upstream of or within cholesterol metabolic process and cholesterol transport. Located in extracellular region. Is expressed in intestine; liver; ovary; ventral telencephalon; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); familial visceral amyloidosis; hypolipoproteinemia (multiple); non-alcoholic steatohepatitis; and systemic lupus erythematosus. Orthologous to human APOA1 (apolipoprotein A1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
20 figures from 13 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With apoa1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
familial visceral amyloidosis Alliance Amyloidosis, 3 or more types 105200
primary hypoalphalipoproteinemia 2 Alliance ApoA-I and apoC-III deficiency, combined 618463
primary hypoalphalipoproteinemia 2 Alliance Hypoalphalipoproteinemia, primary, 2, with or without corneal clouding 618463
Associated With apoa1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR000074 Apolipoprotein A/E
Domain Details Per Protein
Protein Length Apolipoprotein A/E
UniProtKB:O42363 262
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations