| ZFIN ID: ZDB-GENE-990415-14 |
| Gene Name: | apolipoprotein A-Ia | |||||||||||||
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| Gene Symbol: | apoa1a Nomenclature History |
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Attributions
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| Previous Names: | apoa1, apoa, cb49 (1), etID309895.5 (1), etID32161.5 (1), wu:fb33f01 (1), zgc:103718 | |||||||||||||
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| Gene Type: | protein_coding_gene | |||||||||||||
| Location: | Chr: 5 Mapping Details/Browsers | |||||||||||||
| Description: | Predicted to have several functions, including cholesterol binding activity; cholesterol transfer activity; and high-density lipoprotein particle binding activity. Predicted to be involved in several processes, including lipid homeostasis; lipid transport; and plasma lipoprotein particle organization. Localizes to extracellular region. Is expressed in intestine; liver; ovary; ventral telencephalon; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); familial visceral amyloidosis; hypolipoproteinemia; non-alcoholic steatohepatitis; and systemic lupus erythematosus. Orthologous to human APOA1 (apolipoprotein A1). | |||||||||||||
| Genome Resources: | Alliance (1), Gene:30355 (1), Ensembl(GRCz11):ENSDARG00000012076 (1) | |||||||||||||
| All Expression Data: | 20 figures from 13 publications |
| Directly Submitted Expression Data: | 6 figures (2 images) from Thisse et al., 2001 [cb49] |
| Wild-type Stages, Structures: | Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult) |
| High Throughput Expression: | GEO (1) , Expression Atlas (1) |
MUTATIONS AND SEQUENCE TARGETING REAGENTS
| Allele | Type | Localization | Consequence | Mutagen | Suppliers |
|---|---|---|---|---|---|
| sa10582 | Point Mutation | Unknown | Premature Stop | ENU |
|
Sequence Targeting Reagents
| Targeting Reagent | Created Alleles | Publications |
|---|---|---|
| MO1-apoa1a | N/A | 1 |
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial visceral amyloidosis | Alliance | Amyloidosis, 3 or more types | 105200 |
| ApoA-I and apoC-III deficiency, combined | 618463 | ||
| Hypoalphalipoproteinemia, primary, 2, with or without corneal clouding | 618463 |
GENE ONTOLOGY
| Ontology | GO Term |
|---|---|
| Biological Process | cholesterol biosynthetic process (more) |
| Cellular Component | extracellular region (more) |
| Molecular Function | cholesterol transfer activity (more) |
| Type | Name | Length (nt) | Analysis | |
|---|---|---|---|---|
| mRNA |
apoa1a-201
(1)
|
974 |
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|
| Browsers: UCSC, NCBI, Ensembl, ZFIN |
ANTIBODIES
No data available
PLASMIDS
| Addgene:PCRII apoA-Ia |
CONSTRUCTS WITH SEQUENCES FROM apoa1a
| Construct | Regulatory Regions | Coding Sequences | Species | Tg Lines | Publications |
|---|---|---|---|---|---|
| tg(fabp2:apoa1a-mcherry) | fabp2 | apoa1a, mCherry | Danio rerio | 1 | 1 |
| tg(fabp10a:apoa1a-mcherry) | fabp10a | apoa1a, mCherry | Danio rerio | 1 | 1 |
MARKER RELATIONSHIPS
| apoa1a Contained in: | [BAC] CH211-139A5 (1) |
| apoa1a Encodes: |
[EST]
cb49 (1) (order this),
fb33f01 (1)
[cDNA] MGC:103718 (1) |
SEQUENCE INFORMATION
| Type | Accession # | Length (nt/aa) | Analysis |
|---|---|---|---|
| RNA | RefSeq:NM_131128 (1) | 1004 nt |
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| Genomic | GenBank:BX465852 (1) | 160041 nt | |
| Polypeptide | UniProtKB:O42363 (1) | 262 aa |
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ORTHOLOGY for apoa1a (
Chr:
5
)
CITATIONS (85)