Gene
apoa1a
- ID
- ZDB-GENE-990415-14
- Name
- apolipoprotein A-Ia
- Symbol
- apoa1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have several functions, including cholesterol binding activity; cholesterol transfer activity; and high-density lipoprotein particle binding activity. Predicted to be involved in several processes, including lipid homeostasis; lipid transport; and plasma lipoprotein particle organization. Localizes to extracellular region. Is expressed in intestine; liver; ovary; ventral telencephalon; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); familial hypercholesterolemia; familial visceral amyloidosis; non-alcoholic steatohepatitis; and systemic lupus erythematosus. Orthologous to human APOA1 (apolipoprotein A1).
- Genome Resources
- Note
- None
- All Expression Data
- 20 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- No data available
- Thisse Expression Data
-
- cb49 (2 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial visceral amyloidosis | Alliance | Amyloidosis, 3 or more types | 105200 |
| ApoA-I and apoC-III deficiency, combined | 618463 | ||
| Hypoalphalipoproteinemia, primary, 2, with or without corneal clouding | 618463 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR000074 | Apolipoprotein A/E |
Domain Details Per Protein
| Protein | Length | Apolipoprotein A/E |
|---|---|---|
|
UniProtKB:O42363
|
262 |
| Type | Name | Length (nt) | Analysis |
|---|---|---|---|
| mRNA |
apoa1a-201
(1)
|
974 nt |
Interactions and Pathways
Plasmids
- Gene Tree
- Ensembl