Gene

apoa1a

ID

ZDB-GENE-990415-14

Name

apolipoprotein A-Ia

Symbol

apoa1a Nomenclature History

Previous Names

apoa1 (1)
apoa
cb49 (1)
etID309895.5 (1)
etID32161.5 (1)
wu:fb33f01 (1)
zgc:103718

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to enable several functions, including cholesterol binding activity; cholesterol transfer activity; and high-density lipoprotein particle binding activity. Predicted to be involved in several processes, including lipid homeostasis; lipid transport; and plasma lipoprotein particle organization. Predicted to act upstream of or within cholesterol metabolic process and cholesterol transport. Located in extracellular region. Is expressed in intestine; liver; ovary; ventral telencephalon; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); familial visceral amyloidosis; hypolipoproteinemia (multiple); non-alcoholic steatohepatitis; and systemic lupus erythematosus. Orthologous to human APOA1 (apolipoprotein A1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

20 figures from 13 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

Thisse Expression Data

cb49 (2 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With apoa1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
familial visceral amyloidosis	Alliance	Amyloidosis, 3 or more types	105200
primary hypoalphalipoproteinemia 2	Alliance	ApoA-I and apoC-III deficiency, combined	618463
primary hypoalphalipoproteinemia 2	Alliance	Hypoalphalipoproteinemia, primary, 2, with or without corneal clouding	618463