ZFIN ID: ZDB-GENE-990415-14 |
Gene Name: | apolipoprotein A-Ia | ||||||
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Gene Symbol: | apoa1a Nomenclature History | ||||||
Previous Names: | apoa1, apoa, cb49 (1), etID309895.5 (1), etID32161.5 (1), wu:fb33f01 (1), zgc:103718 | ||||||
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Gene Type: | protein_coding_gene | ||||||
Location: | Chr: 5 Mapping Details/Browsers | ||||||
Description: | Predicted to have several functions, including cholesterol binding activity; cholesterol transfer activity; and high-density lipoprotein particle binding activity. Predicted to be involved in several processes, including lipid homeostasis; lipid transport; and plasma lipoprotein particle organization. Localizes to the extracellular region. Human ortholog(s) of this gene implicated in Alzheimer's disease; artery disease (multiple); familial visceral amyloidosis; hypolipoproteinemia; and systemic lupus erythematosus. Is expressed in intestine; liver; ovary; ventral telencephalon; and yolk syncytial layer. Orthologous to human APOA1 (apolipoprotein A1). | ||||||
Genome Resources: | Alliance (1), Gene:30355 (1), Ensembl(GRCz11):ENSDARG00000012076 (1) |
All Expression Data: | 19 figures from 12 publications |
Directly Submitted Expression Data: | 6 figures (2 images) from Thisse et al., 2001 [cb49] |
Wild-type Stages, Structures: | Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult) |
Curated Microarray Expression: | GEO (1) |
Allele | Type | Localization | Consequence | Mutagen | Suppliers |
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sa10582 | Point Mutation | Unknown | Premature Stop | ENU |
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Targeting Reagent | Created Alleles | Publications |
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MO1-apoa1a | N/A | 1 |
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
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familial visceral amyloidosis | Alliance | Amyloidosis, 3 or more types | 105200 |
ApoA-I and apoC-III deficiency, combined | 618463 | ||
Hypoalphalipoproteinemia, primary, 2, with or without corneal clouding | 618463 |
Ontology | GO Term |
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Biological Process | cholesterol biosynthetic process (more) |
Cellular Component | extracellular region (more) |
Molecular Function | cholesterol transfer activity (more) |
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Type | Name | Length (nt) | Analysis | |
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mRNA |
apoa1a-201
(1)
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974 |
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Browsers: UCSC, NCBI, Ensembl, ZFIN |
Addgene:PCRII apoA-Ia |
Construct | Regulatory Regions | Coding Sequences | Species | Tg Lines | Publications |
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tg(fabp2:apoa1a-mcherry) | fabp2 | apoa1a, mCherry | Danio rerio | 1 | 1 |
tg(fabp10a:apoa1a-mcherry) | fabp10a | apoa1a, mCherry | Danio rerio | 1 | 1 |
apoa1a Contained in: | [BAC] CH211-139A5 (1) (order this) |
apoa1a Encodes: |
[EST]
cb49 (1) (order this),
fb33f01 (1)
[cDNA] MGC:103718 (1) (order this) |
Type | Accession # | Length (bp/aa) | Analysis |
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RNA | RefSeq:NM_131128 (1) | 1004 bp |
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Genomic | GenBank:BX465852 (1) | 160041 bp | |
Polypeptide | UniProtKB:O42363 (1) | 262 aa |
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Sequence Clusters | UniGene:75775 (1) |