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ZIRC
ZFIN ID: ZDB-GENE-990415-14
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Gene Name: apolipoprotein A-Ia
Gene Symbol: apoa1a    Nomenclature History

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Previous Names: apoa1, apoa, cb49 (1), etID309895.5 (1), etID32161.5 (1), wu:fb33f01 (1), zgc:103718

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have several functions, including cholesterol binding activity; cholesterol transfer activity; and high-density lipoprotein particle binding activity. Predicted to be involved in several processes, including lipid homeostasis; lipid transport; and plasma lipoprotein particle organization. Localizes to the extracellular region. Human ortholog(s) of this gene implicated in Alzheimer's disease; artery disease (multiple); familial visceral amyloidosis; hypolipoproteinemia; and systemic lupus erythematosus. Is expressed in intestine; liver; ovary; ventral telencephalon; and yolk syncytial layer. Orthologous to human APOA1 (apolipoprotein A1).
Genome Resources: Alliance (1),  Gene:30355 (1),  Ensembl(GRCz11):ENSDARG00000012076 (1)
GENE EXPRESSION
All Expression Data: 19 figures from 12 publications
Directly Submitted Expression Data: 6 figures (2 images) from Thisse et al., 2001 [cb49]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa10582 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-apoa1a N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH apoa1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    familial visceral amyloidosis Alliance Amyloidosis, 3 or more types 105200
    ApoA-I and apoC-III deficiency, combined 618463
    Hypoalphalipoproteinemia, primary, 2, with or without corneal clouding 618463
    DISEASE ASSOCIATED WITH apoa1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cholesterol biosynthetic process (more)
    Cellular Component extracellular region (more)
    Molecular Function cholesterol transfer activity (more)
    GO Terms (all 27)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000074 (1)
  • Pfam:PF01442 (1)
    • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA apoa1a-201 (1)    Ensembl 974
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS
    Addgene:PCRII apoA-Ia
    CONSTRUCTS WITH SEQUENCES FROM apoa1a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    tg(fabp2:apoa1a-mcherry) fabp2 apoa1a,  mCherry Danio rerio 1 1
    tg(fabp10a:apoa1a-mcherry) fabp10a apoa1a,  mCherry Danio rerio 1 1
    MARKER RELATIONSHIPS
    apoa1a Contained in: [BAC] CH211-139A5 (1) (order this)
    apoa1a Encodes: [EST] cb49 (1) (order this), fb33f01 (1)
    [cDNA] MGC:103718 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131128 (1) 1004 bp
    Select Tool
    Genomic GenBank:BX465852 (1) 160041 bp
    Select Tool
    Polypeptide UniProtKB:O42363 (1) 262 aa
    Select Tool
    Sequence Clusters UniGene:75775 (1)
    Sequence Information (all 17)
    ORTHOLOGY for apoa1a ( Chr: 5 )
    CITATIONS (81)