ZFIN ID: ZDB-GENE-980526-464
Gene Name: v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog a
Gene Symbol: kita
Sequence Ontology ID : SO:0000704

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Previous Names: c-kit, kit, spa-1 (1), spa, sparse

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(Including Attributions)
Location: Chr: 20 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 31 figures from 19 publications
Directly Submitted Expression Data: 6 figures (33 images) from Thisse et al., 2008 [cssl:d114]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult)
  anterior axial hypoblast, anterior commissure, brain posterior side, caudal commissure (all 41) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b5 Small Deletion Unknown Frameshift SPONTANEOUS
  • Zebrafish International Resource Center (ZIRC) (order this)
  • b134 Unknown Unknown Unknown G_RAYS
    j1e1 Point Mutation Unknown Unknown ENU
    j1e15 Unknown Unknown Unknown
    j1e41 Point Mutation Unknown Unknown ENU
    j1e56 Point Mutation Unknown Unknown ENU
    j1e60 Point Mutation Unknown Missense ENU
    j1e78 Point Mutation Unknown Missense ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • j1e89 Point Mutation Unknown Missense ENU
    j1e99 Point Mutation Unknown Missense ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • j1e177 Point Mutation Unknown Missense ENU
    j1e249 Point Mutation Unknown Missense ENU
    kita_unspecified Unspecified Unknown Unknown
    m141 Unknown Unknown Unknown ENU
    m442 Unknown Unknown Unknown ENU
    m443 Unknown Unknown Unknown ENU
    sa6630 Point Mutation Unknown Premature Stop ENU
    sa18325 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa29347 Point Mutation Unknown Premature Stop ENU
    sa37018 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • te237 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • th35c Unknown Unknown Unknown ENU
    tj245 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tm18b Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tm63a Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tm102c Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tm228 Unknown Unknown Unknown ENU
    to75b Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tp44 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • w34b Small Deletion Exon 10 Unknown ENU
    Targeting reagents: MO1-kita (1)
    PHENOTYPE
    Data: 52 figures from 19 publications
    Observed in: gut, head melanocyte, lateral larval melanophore stripe melanocyte, melanoblast (all 20) expand
    DISEASE ASSOCIATED WITH kita HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    acute myeloid leukemia Leukemia, acute myeloid 601626
    gastrointestinal stromal tumor Gastrointestinal stromal tumor, familial 606764
    mastocytosis Mast cell disease 154800
    piebaldism Piebaldism 172800
    seminoma Germ cell tumors 273300
    testicular cancer Germ cell tumors 273300
    testicular germ cell cancer Germ cell tumors 273300
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process developmental pigmentation (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 26)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR001824 (1)
  • InterPro:IPR003598 (1)
  • InterPro:IPR003599 (1)
  • InterPro:IPR007110 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020635 (1)
  • InterPro:IPR027263 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS00240 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50835 (1)
  • Pfam:PF07714 (1)
  • EC:2.7.10.1 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA kita-001 (1) 3543
    kita-002 (1) 3138
    ottdart00000047646 (1) 3543
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Ab2-kita (1)
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM kita
    Et(kita:GAL4TA4,UAS:mCherry), Tg(kita:GAL4), tgbac(kita:lexpr-cerulean)
    MARKER RELATIONSHIPS
    kitaContained in: [BAC] CH211-176L11 (1) (order this), DKEY-97C6 (1) (order this), DKEY-204O9 (1) (order this)
    [PAC] BUSM1-116L04 (1) (order this), BUSM1-205D10 (order this)
    kitaEncodes: [cDNA] cssl:d114 (1) (order this), MGC:193630 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131053 (1) 3545bp
    Genomic GenBank:BX276097 (1) 216655bp Blast at MegaBLAST
    Polypeptide UniProtKB:B3DGS5 (1) 981aa
    Sequence Clusters UniGene:81312 (1)
    Sequence Information (all 30)
    OTHER kita GENE PAGES
  • Alliance (1)
  • Gene:30256 (1)
  • VEGA:OTTDARG00000004843 (1)
  • VEGA:OTTDARG00000033805 (1)
  • Ensembl(GRCz10):ENSDARG00000043317 (1)
  • ORTHOLOGY for kita (Chr: 20)
    CITATIONS (114)