Gene

myh14

ID

ZDB-GENE-100921-1

Name

myosin, heavy chain 14, non-muscle

Symbol

myh14 Nomenclature History

Previous Names

si:ch211-120k19.2
si:ch211-120k19.3

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Predicted to localize to myosin complex. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 4A and sensorineural hearing loss. Orthologous to human MYH14 (myosin heavy chain 14).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

Thisse Expression Data

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With myh14 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 4A	Alliance	Deafness, autosomal dominant 4A	600652
		?Peripheral neuropathy, myopathy, hoarseness, and hearing loss	614369

Associated With myh14 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR000048	IQ motif, EF-hand binding site
Domain	IPR001609	Myosin head, motor domain
Domain	IPR002928	Myosin tail
Domain	IPR004009	Myosin, N-terminal, SH3-like
Homologous_superfamily	IPR008989	Myosin S1 fragment, N-terminal
Homologous_superfamily	IPR027401	Myosin IQ motif-containing domain superfamily
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036961	Kinesin motor domain superfamily

Domain Details Per Protein

Protein	Length	IQ motif, EF-hand binding site	Kinesin motor domain superfamily	Myosin head, motor domain	Myosin IQ motif-containing domain superfamily	Myosin, N-terminal, SH3-like	Myosin S1 fragment, N-terminal	Myosin tail	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:E7FGF6 InterPro	2011
UniProtKB:A0A140LGG8 InterPro	144
UniProtKB:E9QFE1 InterPro	2020

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Length (nt)	Analysis
mRNA	myh14-203 (1) Ensembl	12826 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	myh14-204 (1) Ensembl	446 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	myh14-002 (1) Ensembl	529 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations