Gene
rfx2
- ID
- ZDB-GENE-050227-4
- Name
- regulatory factor X, 2 (influences HLA class II expression)
- Symbol
- rfx2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in Kupffer's vesicle development and determination of left/right symmetry. Predicted to localize to nucleus. Is expressed in several structures, including central nervous system; mesoderm; neural plate; neural tube; and pronephros. Orthologous to human RFX2 (regulatory factor X2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 38 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb7 (16 images)
- cb133 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Bisgrove et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003150 | DNA-binding RFX-type winged-helix domain |
| Domain | IPR007668 | RFX1 transcription activation region |
| Family | IPR039779 | RFX-like DNA-binding protein |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | DNA-binding RFX-type winged-helix domain | RFX1 transcription activation region | RFX-like DNA-binding protein | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:Q5EAP5
|
734 | |||||
|
UniProtKB:A0A8M2BEA3
|
704 | |||||
|
UniProtKB:A0A8M2BEC2
|
709 |
Interactions and Pathways
No data available
Plasmids
No data available