Gene

rfx2

ID
ZDB-GENE-050227-4
Name
regulatory factor X, 2 (influences HLA class II expression)
Symbol
rfx2 Nomenclature History
Previous Names
  • cb133 (1)
  • cb7 (1)
  • sb:cb133
  • sb:cb7
  • wu:fd20b11
  • zgc:91808
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in Kupffer's vesicle development and determination of left/right symmetry. Predicted to localize to nuclear chromatin. Is expressed in several structures, including central nervous system; mesoderm; neural plate; neural tube; and pronephros. Orthologous to human RFX2 (regulatory factor X2).
Genome Resources
Note
None
Expression
All Expression Data
36 figures from 12 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Bisgrove et al., 2012
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With rfx2 Human Ortholog
No data available
Associated With rfx2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003150 DNA-binding RFX-type winged-helix domain
Domain IPR007668 RFX1 transcription activation region
Family IPR039779 RFX-like DNA-binding protein
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length DNA-binding RFX-type winged-helix domain RFX1 transcription activation region RFX-like DNA-binding protein Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:E9QJ42 189
UniProtKB:E9QCU4 170
UniProtKB:E9QEW4 234
UniProtKB:Q5EAP5 734
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations