ZFIN ID: ZDB-GENE-040718-101
Gene Name: glutaredoxin 2
Gene Symbol: glrx2    Nomenclature History

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Previous Names: grx2 (1), zgc:92698

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Exhibits oxidoreductase activity. Involved in central nervous system development; circulatory system development; and protein deglutathionylation. Localizes to cytosol. Is expressed in neurons. Orthologous to human GLRX2 (glutaredoxin 2).
Genome Resources: Alliance (1),  Gene:436677 (1),  Ensembl(GRCz11):ENSDARG00000100944 (1)
GENE EXPRESSION
All Expression Data: 4 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:92698]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa37514 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-glrx2 N/A 3
    DISEASE ASSOCIATED WITH glrx2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH glrx2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein deglutathionylation (more)
    Cellular Component cytosol (more)
    Molecular Function oxidoreductase activity (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA glrx2-201 (1)    Ensembl 1003
    glrx2-202 (1)    Ensembl 575
    glrx2-203 (1)    Ensembl 788
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-glrx2 polyclonal Rabbit IHC 2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM glrx2 No data available
    MARKER RELATIONSHIPS
    glrx2 Contained in: [BAC] CH73-13N19 (1), DKEY-53B10 (1) (order this)
    [Fosmid] CH1073-390F18 (1)
    glrx2 Encodes: [cDNA] MGC:92698 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001002404 (1) 877 nt
    Genomic GenBank:BX936311 192750 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4ILJ8 (1) 170 aa
    Sequence Information (all 22)
    ORTHOLOGY for glrx2 ( Chr: 22 )
    CITATIONS (23)