ZFIN ID: ZDB-GENE-040624-11
Gene Name: blood vessel epicardial substance
Gene Symbol: bves    Nomenclature History

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Previous Names: pop1 (1), popdc1 (1), zgc:86887

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have cAMP binding activity and structural molecule activity. Involved in several processes, including animal organ development; bicellular tight junction assembly; and skeletal myofibril assembly. Localizes to the sarcolemma. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2X. Is expressed in several structures, including EVL; cardiovascular system; eye; integument; and optic vesicle. Orthologous to human BVES (blood vessel epicardial substance).
Genome Resources: Alliance (1),  Gene:415107 (1),  Ensembl(GRCz11):ENSDARG00000058548 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
icl1 Point Mutation Unknown Unknown TALEN
sa42658 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-bves N/A 2
    MO2-bves N/A 3
    MO3-bves N/A 1
    MO4-bves N/A 1
    MO5-bves N/A 1
    TALEN1-bves 1
    DISEASE ASSOCIATED WITH bves HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal recessive limb-girdle muscular dystrophy type 2X Alliance Muscular dystrophy, limb-girdle, autosomal recessive 25 616812
    DISEASE ASSOCIATED WITH bves VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process bicellular tight junction assembly (more)
    Cellular Component sarcolemma (more)
    Molecular Function structural molecule activity (more)
    GO Terms (all 35)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR006916 Popeye protein
    Homologous_superfamily IPR014710 RmlC-like jelly roll fold
    Homologous_superfamily IPR018490 Cyclic nucleotide-binding-like
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA bves-201 (1)    Ensembl 1771
    bves-202 (1)    Ensembl 1798
    bves-203 (1)    Ensembl 1827
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-bves polyclonal Rabbit IHC 2
    Ab2-bves polyclonal Rabbit IHC Sigma-Aldrich
    1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM bves
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(bves:EGFP) bves EGFP Danio rerio 1 1
    MARKER RELATIONSHIPS
    bves Contained in: [BAC] DKEY-278K10 (1) (order this)
    bves Encodes: [EST] IMAGE:6907272 (1)
    [cDNA] MGC:86887 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001001847 (1) 1883 bp
    Genomic GenBank:BX511173 (1) 163044 bp
    Select Tool
    Polypeptide UniProtKB:G9HVJ5 (1) 352 aa
    Sequence Clusters UniGene:81725 (1)
    Sequence Information (all 24)
    ORTHOLOGY for bves ( Chr: 16 )
    CITATIONS (26)