Gene

mycb

ID
ZDB-GENE-040426-780
Name
MYC proto-oncogene, bHLH transcription factor b
Symbol
mycb Nomenclature History
Previous Names
  • cmycb
  • C-Myc2 (1)
  • zgc:55680
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in definitive hemopoiesis and hematopoietic progenitor cell differentiation. Predicted to localize to nucleus. Is expressed in several structures, including caudal vein plexus; intestine; nervous system; presumptive neural retina; and shield. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); demyelinating disease; hematologic cancer (multiple); prostate cancer (multiple); and urinary bladder cancer. Orthologous to human MYC (MYC proto-oncogene, bHLH transcription factor).
Genome Resources
Note
None
Expression
All Expression Data
22 figures from 16 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
Fig. 4 from Lin et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mycb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Burkitt lymphoma Alliance Burkitt lymphoma, somatic 113970
Associated With mycb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003327 Leucine zipper, Myc
Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Domain IPR012682 Transcription regulator Myc, N-terminal
Family IPR002418 Transcription regulator Myc
Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Helix-loop-helix DNA-binding domain superfamily Leucine zipper, Myc Myc-type, basic helix-loop-helix (bHLH) domain Transcription regulator Myc Transcription regulator Myc, N-terminal
UniProtKB:Q7ZVS9 396
UniProtKB:B0UY65 257
UniProtKB:B2GQB7 396
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations