Gene

atp2a2a

ID
ZDB-GENE-040426-702
Name
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2a
Symbol
atp2a2a Nomenclature History
Previous Names
  • atp2a2 (1)
  • serca2 (1)
  • zgc:55380 (1)
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have ATPase activity; calcium transmembrane transporter activity, phosphorylative mechanism; and proton-exporting ATPase activity, phosphorylative mechanism. Involved in heart looping and regulation of heart contraction. Predicted to localize to sarcoplasmic reticulum membrane. Is expressed in cardiovascular system; musculature system; pectoral fin; polster; and somite. Human ortholog(s) of this gene implicated in acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Orthologous to human ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2).
Genome Resources
Note
None
Expression
All Expression Data
19 figures from 12 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
Fig. 4 from Ebert et al., 2005
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With atp2a2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acrokeratosis verruciformis Alliance Acrokeratosis verruciformis 101900
keratosis follicularis Alliance Darier disease 124200
Associated With atp2a2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR004014 Cation-transporting P-type ATPase, N-terminal
Domain IPR006068 Cation-transporting P-type ATPase, C-terminal
Family IPR001757 P-type ATPase
Family IPR005782 P-type ATPase, subfamily IIA, SERCA-type
Homologous_superfamily IPR008250 P-type ATPase, A domain superfamily
Homologous_superfamily IPR023214 HAD superfamily
Homologous_superfamily IPR023298 P-type ATPase, transmembrane domain superfamily
Homologous_superfamily IPR023299 P-type ATPase, cytoplasmic domain N
Homologous_superfamily IPR036412 HAD-like superfamily
PTM IPR018303 P-type ATPase, phosphorylation site
Domain Details Per Protein
Protein Length Cation-transporting P-type ATPase, C-terminal Cation-transporting P-type ATPase, N-terminal HAD-like superfamily HAD superfamily P-type ATPase P-type ATPase, A domain superfamily P-type ATPase, cytoplasmic domain N P-type ATPase, phosphorylation site P-type ATPase, subfamily IIA, SERCA-type P-type ATPase, transmembrane domain superfamily
UniProtKB:E9QEP4 55
UniProtKB:B2GRT2 996
UniProtKB:A9C3Q5 996
UniProtKB:A9C3Q4 1042
UniProtKB:Q7ZW18 996
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-atp2a2a polyclonal IgG Rabbit
GeneTex
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations