ZFIN ID: ZDB-GENE-040426-702
Gene Name: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2a
Gene Symbol: atp2a2a    Nomenclature History

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Previous Names: atp2a2 (1), serca2 (1), zgc:55380 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have ATPase activity; calcium transmembrane transporter activity, phosphorylative mechanism; and proton-exporting ATPase activity, phosphorylative mechanism. Involved in heart looping and regulation of heart contraction. Predicted to localize to sarcoplasmic reticulum membrane. Is expressed in cardiovascular system; musculature system; pectoral fin; polster; and somite. Human ortholog(s) of this gene implicated in acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Orthologous to human ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2).
Genome Resources: Alliance (1),  Gene:393940 (1),  Ensembl(GRCz11):ENSDARG00000029439 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa13962 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa27138 Point Mutation Unknown Premature Stop ENU
    sa34332 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41137 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-atp2a2a
    1
    MO1-atp2a2a N/A 2
    DISEASE ASSOCIATED WITH atp2a2a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    acrokeratosis verruciformis Alliance Acrokeratosis verruciformis 101900
    keratosis follicularis Alliance Darier disease 124200
    DISEASE ASSOCIATED WITH atp2a2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process heart looping (more)
    Cellular Component endoplasmic reticulum (more)
    Molecular Function ATP binding (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript atp2a2a-202 (1)    Ensembl 798
    mRNA atp2a2a-201 (1)    Ensembl 3724
    atp2a2a-203 (1)    Ensembl 3186
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-atp2a2a polyclonal IgG Rabbit GeneTex
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM atp2a2a No data available
    MARKER RELATIONSHIPS
    atp2a2a Contained in: [BAC] DKEY-252G21 (1) (order this)
    atp2a2a Encodes: [EST] IMAGE:7165932 (1)
    [cDNA] MGC:55380 (1), MGC:193107 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200965 (1) 3738 nt
    Genomic GenBank:CR407563 (1) 109914 nt
    Select Tool
    Polypeptide UniProtKB:A9C3Q4 (1) 1042 aa
    Sequence Information (all 23)
    ORTHOLOGY for atp2a2a ( Chr: 8 )
    CITATIONS (58)