ZFIN ID: ZDB-GENE-040426-1087
Gene Name: ADP-ribosylation factor-like 6 interacting protein 1
Gene Symbol: arl6ip1    Nomenclature History

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Previous Names: arl6ip (1), zgc:56593 (1), zgc:77873

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Involved in neural crest cell migration and retina morphogenesis in camera-type eye. Predicted to localize to Sec61 translocon complex and integral component of membrane. Is expressed in several structures, including blastodisc; central nervous system; hypochord; optic cup; and retina. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 61. Orthologous to human ARL6IP1 (ADP ribosylation factor like GTPase 6 interacting protein 1).
Genome Resources: Alliance (1),  Gene:394087 (1),  Ensembl(GRCz11):ENSDARG00000054578 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la028894Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-arl6ip1 N/A 4
    MO2-arl6ip1 N/A 2
    DISEASE ASSOCIATED WITH arl6ip1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hereditary spastic paraplegia 61 Alliance ?Spastic paraplegia 61, autosomal recessive 615685
    DISEASE ASSOCIATED WITH arl6ip1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process neural crest cell development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function protein binding (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA arl6ip1-201 (1)    Ensembl 1590
    arl6ip1-202 (1)    Ensembl 615
    ncRNA arl6ip1-003 (1)    Ensembl 781
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-arl6ip1 polyclonal IgG Rabbit WB Abcam plc
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM arl6ip1 No data available
    MARKER RELATIONSHIPS
    arl6ip1 Contained in: [BAC] DKEY-66I24 (1) (order this)
    arl6ip1 Encodes: [EST] IMAGE:7140611 (1)
    [cDNA] MGC:56593 (1), MGC:77873 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_201112 (1) 1545 nt
    Genomic GenBank:BX004999 (1) 168839 nt
    Select Tool
    Polypeptide UniProtKB:Q7ZWB4 (1) 203 aa
    Sequence Information (all 15)
    ORTHOLOGY for arl6ip1 ( Chr: 3 )
    CITATIONS (29)