ZFIN ID: ZDB-GENE-031007-6
Gene Name: Dmx-like 2
Gene Symbol: dmxl2    Nomenclature History

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Previous Names: cb952 (1), rabconnectin3alpha, rbc3a, rbc3alpha, rc3, si:ch211-165a16.2, si:ch211-165a16.3 (1), stardust (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Involved in neural crest cell migration; positive regulation of canonical Wnt signaling pathway; and regulation of vesicle-mediated transport. Predicted to localize to RAVE complex. Is expressed in several structures, including nervous system; neural crest; neural tube; shield; and solid lens vesicle. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 71 and early infantile epileptic encephalopathy. Orthologous to human DMXL2 (Dmx like 2).
Genome Resources: Alliance (1),  Gene:378958 (1),  Ensembl(GRCz11):ENSDARG00000091293 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa23358 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23359 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • t21010 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • t21192 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • t26173 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-dmxl2 N/A 1
    MO2-dmxl2 N/A 1
    DISEASE ASSOCIATED WITH dmxl2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant nonsyndromic deafness 71 Alliance ?Deafness, autosomal dominant 71 617605
    Epileptic encephalopathy, early infantile, 81 618663
    ?Polyendocrine-polyneuropathy syndrome 616113
    DISEASE ASSOCIATED WITH dmxl2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process neural crest cell migration (more)
    Cellular Component RAVE complex (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dmxl2-201 (1)    Ensembl 276
    dmxl2-202 (1)    Ensembl 3321
    ncRNA dmxl2-003 (1)    Ensembl 754
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dmxl2 No data available
    MARKER RELATIONSHIPS
    dmxl2 Contained in: [BAC] CH211-165A16
    dmxl2 Encodes: [EST] cb952 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001302235 (1)
    Genomic GenBank:BX908722 166917 nt
    Select Tool
    Polypeptide UniProtKB:U5U756 (1) 3050 aa
    Sequence Information (all 13)
    ORTHOLOGY for dmxl2 ( Chr: 18 )
    CITATIONS (21)