ZFIN Gene: piwil1

ZFIN ID: ZDB-GENE-030813-2

ZFIN ID: ZDB-GENE-030813-2

Gene Name:

piwi-like RNA-mediated gene silencing 1

Gene Symbol:

piwil1

Sequence Ontology ID :

SO:0000704

Previous Name:

ziwi (1)

Location:

Chr: 8 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Exhibits piRNA binding activity. Involved in several processes, including gene silencing by RNA; germ cell development; and piRNA metabolic process. Localizes to the P granule. Orthologous to several ...

GENE EXPRESSION
All Expression Data:	25 figures from 18 publications
Wild-type Stages, Structures:	Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
	blastodisc P granule central nervous system diencephalon eye germ line cell gonad immature gonad lens midbrain oocyte oocyte stage I ovarian follicle stage I ovarian follicle stage IV ovary germ line cell ovary pectoral fin primordial germ cell P granule primordial germ cell retinal neural layer spermatocyte spermatogonium testis germ line cell testis unfertilized egg whole organism anterior-posterior axis whole organism
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
fh219	Point Mutation	Unknown	Premature Stop	ENU	China Zebrafish Resource Center (CZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
fh220	Point Mutation	Unknown	Unknown	ENU
fh221	Point Mutation	Unknown	Unknown	ENU
hu2410	Point Mutation	Unknown	Unknown	ENU
hu2479	Point Mutation	Unknown	Premature Stop	ENU
la016400Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
la026576Tg	Transgenic Insertion	Unknown	Unknown	DNA
piwil1_unrecovered	Point Mutation	Unknown	Unknown	ENU
sa7619	Point Mutation	Unknown	Missense	ENU
sa8531	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa30904	Point Mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)
sa45333	Point Mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)

PHENOTYPE

Data:	2 figures from Houwing et al., 2007
Observed in:	germ line cell gonad sperm whole organism

DISEASE ASSOCIATED WITH piwil1 HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH piwil1 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	anatomical structure morphogenesis (more)
Cellular Component	cytoplasm (more)
Molecular Function	piRNA binding (more)

GO Terms (all 22)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR003100 (1) InterPro:IPR003165 (1) InterPro:IPR012337 (1) InterPro:IPR031320 (1) InterPro:IPR031326 (1) InterPro:IPR036085 (1) InterPro:IPR036397 (1)	PROSITE:PS50821 (1) PROSITE:PS50822 (1)	Pfam:PF02170 (1) Pfam:PF02171 (1) Pfam:PF05831 (1)	EC:3.1.26.- (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
ncRNA	piwil1-002 (1)	1465	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	piwil1-006 (1)	898	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	piwil1-203 (1)	549	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	piwil1-204 (1)	762	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	piwil1-205 (1)	3257	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	piwil1-206 (1)	915	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Withdrawn Transcripts
mRNA	piwil1-004 (1)	540	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION

INTERACTIONS AND PATHWAYS

ANTIBODIES

Ab1-piwil1 (1)
Ab2-piwil1 (1)

PLASMIDSNo data available

CONSTRUCTS WITH SEQUENCES FROM piwil1

MARKER RELATIONSHIPS

piwil1Contained in:

[BAC] CH73-308B14 (1) (order this), DKEY-245G2 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_183338 (1)	3273bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CR450819 (1)	168244bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:Q8UVX0 (1)	858aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:83448 (1)

Sequence Information (all 17)

OTHER piwil1 GENE PAGES

Alliance (1)

Gene:368200 (1)

VEGA:OTTDARG00000020442 (1)

Ensembl(GRCz11):ENSDARG00000041699 (2)

ORTHOLOGY for piwil1 (Chr: 8)

CITATIONS (83)

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