Gene

piwil1

ID

ZDB-GENE-030813-2

Name

piwi-like RNA-mediated gene silencing 1

Symbol

piwil1 Nomenclature History

Previous Names

ziwi (1)

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Exhibits piRNA binding activity. Involved in several processes, including gene silencing by RNA; germ cell development; and piRNA metabolic process. Localizes to P granule. Is expressed in several structures, including blastodisc; central nervous system; eye; reproductive system; and unfertilized egg. Orthologous to several human genes including PIWIL1 (piwi like RNA-mediated gene silencing 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

32 figures from 24 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Houwing et al., 2007
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With piwil1 Human Ortholog

No data available

Associated With piwil1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003100	PAZ domain
Domain	IPR003165	Piwi domain
Domain	IPR031320	GAGE
Family	IPR031326	Piwi-like protein 1
Homologous_superfamily	IPR012337	Ribonuclease H-like superfamily
Homologous_superfamily	IPR036085	PAZ domain superfamily
Homologous_superfamily	IPR036397	Ribonuclease H superfamily

Domain Details Per Protein

Protein	Length	GAGE	PAZ domain	PAZ domain superfamily	Piwi domain	Piwi-like protein 1	Ribonuclease H-like superfamily	Ribonuclease H superfamily
UniProtKB:Q8UVX0 InterPro	858
UniProtKB:A0A0R4IWH9 InterPro	143
UniProtKB:E9QHH1 InterPro	230
UniProtKB:A0A0J9YJF9 InterPro	171

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	piwil1-203 (1) Ensembl	549 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	piwil1-204 (1) Ensembl	762 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	piwil1-205 (1) Ensembl	3257 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	piwil1-206 (1) Ensembl	915 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	piwil1-006 (1) Ensembl	898 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Host Organism	Assay	Citations
Ab2-piwil1	polyclonal	piwil1	Rabbit		1
AB4-piwil1	polyclonal	piwil1	Rabbit	WB	2
Ab1-piwil1	polyclonal	piwil1	Rabbit	IHC WB	6

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations