ZFIN ID: ZDB-GENE-030219-206
Gene Name: IMP (inosine 5'-monophosphate) dehydrogenase 1b
Gene Symbol: impdh1b    Nomenclature History

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Previous Names: id:ibd5035, si:dkey-31f5.7, wu:fa09h11, wu:fa99c03, zgc:113446

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to have IMP dehydrogenase activity. Predicted to be involved in GTP biosynthetic process. Predicted to localize to cytoplasm. Is expressed in several structures, including digestive system; heart; nervous system; notochord; and pigment cell. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 11; retinitis pigmentosa; and retinitis pigmentosa 10. Orthologous to human IMPDH1 (inosine monophosphate dehydrogenase 1).
Genome Resources: Alliance (1),  Gene:338306 (1),  Ensembl(GRCz11):ENSDARG00000029524 (2)
GENE EXPRESSION
All Expression Data: 8 figures from 3 publications
Directly Submitted Expression Data: 1 figure (4 images) from Kudoh et al., 2001 [ibd5035]
  6 figures (8 images) from Thisse et al., 2004 [IMAGE:7137447]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa33452 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33453 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-impdh1b N/A 1
    PHENOTYPE
    Data: Fig. S4 from Li et al., 2015
    Observed in:
    DISEASE ASSOCIATED WITH impdh1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Leber congenital amaurosis 11 Alliance Leber congenital amaurosis 11 613837
    retinitis pigmentosa 10 Alliance Retinitis pigmentosa 10 180105
    DISEASE ASSOCIATED WITH impdh1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process GMP biosynthetic process (more)
    Cellular Component cytoplasm (more)
    Molecular Function catalytic activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA impdh1b-201 (1)    Ensembl 3206
    impdh1b-202 (1)    Ensembl 3149
    impdh1b-203 (1)    Ensembl 540
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM impdh1b No data available
    MARKER RELATIONSHIPS
    impdh1b Contained in: [BAC] DKEY-31F5 (1) (order this)
    impdh1b Encodes: [EST] fa09h11, fa99c03 (1), ibd5035, IMAGE:7137447 (1)
    [cDNA] MGC:113446
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001014369 (1) 3115 nt
    Genomic GenBank:BX649534 (1) 205347 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q5RGV0 (1) 539 aa
    Sequence Information (all 34)
    ORTHOLOGY for impdh1b ( Chr: 4 )
    CITATIONS (32)