ZFIN ID: ZDB-GENE-040704-15
Gene Name: IMP (inosine 5'-monophosphate) dehydrogenase 1a
Gene Symbol: impdh1a    Nomenclature History

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Previous Name: zgc:91911

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have IMP dehydrogenase activity. Involved in developmental pigmentation and eye development. Predicted to localize to the cytoplasm. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 11; retinitis pigmentosa; and retinitis pigmentosa 10. Is expressed in brain; digestive system; heart; muscle; and sensory system. Orthologous to human IMPDH1 (inosine monophosphate dehydrogenase 1).
Genome Resources: Alliance (1),  Gene:431724 (1),  Ensembl(GRCz11):ENSDARG00000042336 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la020548Tg Transgenic Insertion Unknown Unknown DNA
sa9932 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15860 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16224 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23234 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43048 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-impdh1a N/A 1
    DISEASE ASSOCIATED WITH impdh1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Leber congenital amaurosis 11 Alliance Leber congenital amaurosis 11 613837
    retinitis pigmentosa 10 Alliance Retinitis pigmentosa 10 180105
    DISEASE ASSOCIATED WITH impdh1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process developmental pigmentation (more)
    Cellular Component cytoplasm (more)
    Molecular Function catalytic activity (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000644 CBS domain
    Domain IPR001093 IMP dehydrogenase/GMP reductase
    Family IPR005990 Inosine-5'-monophosphate dehydrogenase
    Homologous_superfamily IPR013785 Aldolase-type TIM barrel
    Conserved_site IPR015875 IMP dehydrogenase / GMP reductase, conserved site
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA impdh1a-201 (1)    Ensembl 2691
    impdh1a-202 (1)    Ensembl 260
    impdh1a-203 (1)    Ensembl 784
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM impdh1a No data available
    MARKER RELATIONSHIPS
    impdh1a Contained in: [BAC] CH211-184L6 (1), DKEY-95H12 (1) (order this)
    impdh1a Encodes: [cDNA] MGC:91911 (1), MGC:193088 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001002177 (1) 2670 bp
    Genomic GenBank:BX927293 (1) 150199 bp
    Select Tool
    Polypeptide UniProtKB:B2GRR5 (1) 544 aa
    Sequence Information (all 29)
    ORTHOLOGY for impdh1a ( Chr: 18 )
    CITATIONS (30)