Gene

kdm1a

ID
ZDB-GENE-030131-7828
Name
lysine (K)-specific demethylase 1a
Symbol
kdm1a Nomenclature History
Previous Names
  • kdm1
  • aof2
  • lsd1 (1)
  • wu:fb82e06
  • wu:fc51a02
  • wu:fj36a05
  • wu:fj66b06
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to have several functions, including chromatin binding activity; flavin adenine dinucleotide binding activity; and histone demethylase activity (H3-dimethyl-K4 specific). Involved in nervous system development; regulation of hemopoiesis; and regulation of retinoic acid biosynthetic process. Predicted to localize to nuclear chromatin. Is expressed in brain; head; intestine; and spinal cord. Orthologous to human KDM1A (lysine demethylase 1A).
Genome Resources
Note
None
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With kdm1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Cleft palate, psychomotor retardation, and distinctive facial features 616728
Associated With kdm1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR002937 Amine oxidase
Domain IPR007526 SWIRM domain
Family IPR017366 Histone lysine-specific demethylase
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Homologous_superfamily IPR036188 FAD/NAD(P)-binding domain superfamily
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Amine oxidase FAD/NAD(P)-binding domain superfamily Histone lysine-specific demethylase Homeobox-like domain superfamily SWIRM domain Winged helix-like DNA-binding domain superfamily
UniProtKB:F8W460 130
UniProtKB:A0A2R8Q8P2 858
UniProtKB:A0A0P0UQI8 830
UniProtKB:F6NIA2 833
UniProtKB:F8W5U1 273
UniProtKB:F8W3Z9 152
UniProtKB:A0JMQ3 848
UniProtKB:F8W5I7 202
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations