ZFIN Gene: kdm1a

ZFIN ID: ZDB-GENE-030131-7828

ZFIN ID: ZDB-GENE-030131-7828

Gene Name:

lysine (K)-specific demethylase 1a

Gene Symbol:

kdm1a

Sequence Ontology ID :

SO:0000704

Previous Names:

kdm1, aof2, lsd1 (1), wu:fb82e06, wu:fc51a02, wu:fj36a05, wu:fj66b06

Location:

Chr: 17 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Predicted to have several functions, including chromatin binding activity, flavin adenine dinucleotide binding activity, and histone demethylase activity (H3-dimethyl-K4 specific); involved in ...

GENE EXPRESSION
All Expression Data:	3 figures from 3 publications
Wild-type Stages, Structures:	Zygote:1-cell (0.0h-0.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
	brain head intestine spinal cord whole organism
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
it627	Point Mutation	Exon 17	Premature Stop	ENU
sa23095	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa28869	Point Mutation	Unknown	Unknown	ENU
sa36433	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa42949	Point Mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)

Targeting reagents:

PHENOTYPE

Data:	8 figures from 3 publications
Observed in:	angioblastic mesenchymal cell blood circulating cell blood island brain neuron brain endothelial cell erythroblast erythrocyte differentiation hematopoietic system neuroectoderm nucleate erythrocyte optic tectum posterior lateral plate mesoderm swim bladder inflation whole organism

DISEASE ASSOCIATED WITH kdm1a HUMAN ORTHOLOG

Disease Ontology Term	OMIM Term	OMIM Phenotype ID
	Cleft palate, psychomotor retardation, and distinctive facial features	616728

DISEASE ASSOCIATED WITH kdm1a VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	regulation of retinoic acid biosynthetic process (more)
Cellular Component	nucleus (more)
Molecular Function	DNA binding (more)

GO Terms (all 14)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR002937 (1) InterPro:IPR007526 (1) InterPro:IPR009057 (1) InterPro:IPR017366 (1) InterPro:IPR036188 (1) InterPro:IPR036388 (1)	PROSITE:PS50934 (1)	Pfam:PF01593 (1) Pfam:PF04433 (1)	EC:1.-.-.- (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
ncRNA	kdm1a-005 (1)	975	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	kdm1a-006 (1)	1015	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	kdm1a-201 (1)	3367	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	kdm1a-202 (1)	887	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	kdm1a-203 (1)	500	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	kdm1a-204 (1)	456	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	kdm1a-207 (1)	606	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION

INTERACTIONS AND PATHWAYS

ANTIBODIESNo data available

PLASMIDSNo data available

CONSTRUCTS WITH SEQUENCES FROM kdm1a No data available

MARKER RELATIONSHIPS

kdm1aContained in:	[BAC] DKEY-265G24 (1) (order this)
kdm1aEncodes:	[EST] fb82e06, fc51a02, fj36a05, fj66b06

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_001242995 (1)		Select Tool ZFIN BLAST NCBI BLAST MegaBLAST Ensembl UCSC BLAT
Genomic	GenBank:AL844186 (1)	221158bp	Blast at MegaBLAST
Polypeptide	UniProtKB:A0A2R8Q8P2 (1)	858aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:105968 (1)

Sequence Information (all 32)

OTHER kdm1a GENE PAGES

Alliance (1)

Gene:558450 (1)

VEGA:OTTDARG00000035108 (1)

Ensembl(GRCz11):ENSDARG00000060679 (2)

ORTHOLOGY for kdm1a (Chr: 17)

CITATIONS (26)

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