Gene
kdm1a
- ID
- ZDB-GENE-030131-7828
- Name
- lysine (K)-specific demethylase 1a
- Symbol
- kdm1a Nomenclature History
- Previous Names
-
- kdm1
- aof2
- lsd1 (1)
- wu:fb82e06
- wu:fc51a02
- wu:fj36a05
- wu:fj66b06
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Is predicted to enable several functions, including chromatin binding activity; flavin adenine dinucleotide binding activity; and histone demethylase activity (H3-dimethyl-K4 specific). Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Acts upstream of or within nervous system development; regulation of hemopoiesis; and regulation of retinoic acid biosynthetic process. Predicted to be located in nucleus. Is expressed in brain; head; intestine; and spinal cord. Orthologous to human KDM1A (lysine demethylase 1A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 12 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Cleft palate, psychomotor retardation, and distinctive facial features | 616728 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002937 | Amine oxidase |
| Domain | IPR007526 | SWIRM domain |
| Family | IPR017366 | Histone lysine-specific demethylase |
| Homologous_superfamily | IPR009057 | Homeobox-like domain superfamily |
| Homologous_superfamily | IPR036188 | FAD/NAD(P)-binding domain superfamily |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Amine oxidase | FAD/NAD(P)-binding domain superfamily | Histone lysine-specific demethylase | Homeobox-like domain superfamily | SWIRM domain | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0P0UQI8
|
830 | ||||||
|
UniProtKB:F8W5I7
|
202 | ||||||
|
UniProtKB:F8W460
|
130 | ||||||
|
UniProtKB:A0A2R8Q8P2
|
858 | ||||||
|
UniProtKB:A0JMQ3
|
848 | ||||||
|
UniProtKB:F8W3Z9
|
152 | ||||||
|
UniProtKB:F8W5U1
|
273 | ||||||
|
UniProtKB:F6NIA2
|
833 |
Interactions and Pathways
No data available
Plasmids
No data available