ZFIN ID: ZDB-GENE-030131-4907
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Gene Name: neurofibromin 1a
Gene Symbol: nf1a
Sequence Ontology ID : SO:0000704

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Previous Names: nf1 (2), fe06d03, hm:zehn0874 (1), wu:fe06d03, zehn0874

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(Including Attributions)
Location: Chr: 15 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Cleavage:4-cell (1.0h-1.25h) to Larval:Day 4 (96.0h-120.0h)
  blood vasculature, dorsal aorta, head, heart (all 6) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la017552Tg Transgenic Insertion Unknown Unknown DNA
p301 Indel Exon 26 Premature Stop ZINC_FINGER_NUCLEASE
p302 Indel Exon 26 Premature Stop ZINC_FINGER_NUCLEASE
p305 Point Mutation Exon 29 Premature Stop ENU
sa848 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa10931 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa22671 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa22672 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa22673 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa32043 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa35917 Point Mutation Unknown Splice Site ENU
    sa35918 Point Mutation Unknown Premature Stop ENU
    sa39056 Point Mutation Unknown Premature Stop ENU
    sa39057 Point Mutation Unknown Premature Stop ENU
    Targeting reagents: CRISPR1-nf1a (1), MO1-nf1a (1), MO2-nf1a (1), MO3-nf1a (1)
    PHENOTYPE
    Data: 4 figures from 3 publications
    Observed in: atrioventricular valve, blood circulation, intersegmental vessel, memory (all 6) expand
    DISEASE ASSOCIATED WITH nf1a HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    juvenile myelomonocytic leukemia Leukemia, juvenile myelomonocytic 607785
    neurofibromatosis Neurofibromatosis, familial spinal 162210
    Neurofibromatosis, type 1 162200
    Neurofibromatosis-Noonan syndrome 601321
    Watson syndrome 193520
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process blood vessel development (more)
    Cellular Component cytoplasm (more)
    Molecular Function GTPase activator activity (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001251 (1)
  • InterPro:IPR001936 (1)
  • InterPro:IPR008936 (1)
  • InterPro:IPR011989 (1)
  • InterPro:IPR016024 (1)
  • InterPro:IPR023152 (1)
  • InterPro:IPR028553 (1)
    		•
  • PROSITE:PS00509 (1)
  • PROSITE:PS50018 (1)
  • PROSITE:PS50191 (1)
    		•
  • Pfam:PF00616 (1)
  • Pfam:PF13716 (1)
    		•
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA nf1a-001 (1) 11386
    Select Tool
    nf1a-002 (1) 689
    Select Tool
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Ab1-nf1 (1)
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM nf1a No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    nf1aContained in: [BAC] CH211-209M20 (1) (order this)
    nf1aContains: [STS] stsnf1 (1)
    nf1aEncodes: [EST] fe06d03, zehn0874
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_009291764 (1) 11426bp
    Select Tool
    Genomic GenBank:BX000438 (1) 195087bp
    Select Tool
    Polypeptide UniProtKB:E7FBD0 (1) 2777aa
    Select Tool
    Sequence Clusters UniGene:105499 (1)
    Sequence Information (all 31)
    OTHER nf1a GENE PAGES
  • Gene:326708 (1)
  • VEGA:OTTDARG00000040134 (1)
  • Ensembl(GRCz10):ENSDARG00000012982 (1)
    • ORTHOLOGY for nf1a (Chr: 15)
    CITATIONS (30)