ZFIN ID: ZDB-GENE-091111-4
Gene Name: neurofibromin 1b
Gene Symbol: nf1b    Nomenclature History

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Previous Name: si:dkey-15g19.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Involved in several processes, including circulatory system development; learning or memory; and neurogenesis. Human ortholog(s) of this gene implicated in autistic disorder; hematologic cancer (multiple); malignant glioma; neurofibromatosis 1; and optic nerve glioma. Is expressed in blood vasculature; dorsal aorta; head; heart; and spinal cord. Orthologous to human NF1 (neurofibromin 1).
Genome Resources: Alliance (1),  Gene:564518 (1),  Ensembl(GRCz11):ENSDARG00000004184 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Cleavage:4-cell (1.0h-1.25h) to Larval:Day 4 (96.0h-120.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
p303 Indel Exon 17 Premature Stop ZINC_FINGER_NUCLEASE
p304 Indel Exon 17 Premature Stop ZINC_FINGER_NUCLEASE
sa16515 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21786 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa27657 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa27658 Point Mutation Unknown Premature Stop ENU
    sa34960 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41713 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-nf1b
    1
    MO1-nf1b N/A 1
    MO2-nf1b N/A 2
    PHENOTYPE
    Data: 2 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH nf1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    juvenile myelomonocytic leukemia Alliance Leukemia, juvenile myelomonocytic 607785
    neurofibromatosis Alliance Neurofibromatosis, familial spinal 162210
    neurofibromatosis 1 Alliance Neurofibromatosis, familial spinal 162210
    Neurofibromatosis, type 1 162200
    neurofibromatosis-Noonan syndrome Alliance Neurofibromatosis-Noonan syndrome 601321
    Watson syndrome 193520
    DISEASE ASSOCIATED WITH nf1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process blood vessel development (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR023152 Ras GTPase-activating protein, conserved site
    Domain IPR001251 CRAL-TRIO lipid binding domain
    Domain IPR001936 Ras GTPase-activating domain
    Family IPR039360 Ras GTPase-activating protein
    Homologous_superfamily IPR008936 Rho GTPase activation protein
    Homologous_superfamily IPR011993 PH-like domain superfamily
    Homologous_superfamily IPR016024 Armadillo-type fold
    Homologous_superfamily IPR036865 CRAL-TRIO lipid binding domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nf1b-201 (1)    Ensembl 8675
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-nf1 polyclonal IgG Rabbit WB Abcam plc
    1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nf1b No data available
    MARKER RELATIONSHIPS
    nf1b Contained in: [BAC] CH73-19D19 (1), DKEY-15G19 (1) (order this), DKEY-174L22 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_005169189 (1) 9061 nt
    Genomic GenBank:CT573181 (1) 143897 nt
    Select Tool
    Polypeptide UniProtKB:E7FFY1 (1) 2759 aa
    Sequence Information (all 11)
    ORTHOLOGY for nf1b ( Chr: 10 )
    CITATIONS (30)