ZFIN ID: ZDB-GENE-030131-106
Gene Name: cathepsin La
Gene Symbol: ctsla    Nomenclature History

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Previous Names: ctsl1a, cb143 (1), hm:zeh1631, ik:tdsubc_2d2, ik:tdsubc_2f10, sb:cb143, tdsubc_2f10, wu:fb70e06, wu:fi15c08, xx:tdsubc_2d2, xx:tdsubc_2f10

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in cellular protein catabolic process. Predicted to localize to extracellular space and lysosome. Is expressed in blood; gill; liver; pleuroperitoneal region; and yolk syncytial layer. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to human CTSL (cathepsin L).
Genome Resources: Alliance (1),  Gene:321453 (1),  Ensembl(GRCz11):ENSDARG00000007836 (2)
GENE EXPRESSION
All Expression Data: 7 figures from 2 publications
Directly Submitted Expression Data: 5 figures (5 images) from Thisse et al., 2001 [cb143]
Wild-type Stages, Structures: Cleavage:16-cell (1.5h-1.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa6998 Point Mutation Unknown Premature Stop ENU
sa20514 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40539 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ctsla HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ctsla VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process proteolysis (more)
    Cellular Component extracellular space (more)
    Molecular Function cysteine-type peptidase activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ctsla-201 (1)    Ensembl 1518
    ctsla-203 (1)    Ensembl 768
    ctsla-204 (1)    Ensembl 947
    ncRNA ctsla-004 (1)    Ensembl 878
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ctsla No data available
    MARKER RELATIONSHIPS
    ctsla Contained in: [BAC] DKEY-250N8 (1) (order this)
    ctsla Encodes: [EST] cb143 (1) (order this), fb70e06, fi15c08, tdsubc_2d2, tdsubc_2f10, zeh1631
    [cDNA] MGC:76945 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212584 (1) 1426 nt
    Genomic GenBank:CT025745 (1) 77308 nt
    Select Tool
    Polypeptide UniProtKB:A5WVL6 (1) 337 aa
    Sequence Information (all 28)
    ORTHOLOGY for ctsla ( Chr: 5 )
    CITATIONS (35)