ZFIN ID: ZDB-GENE-021030-4
Gene Name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Gene Symbol: cad    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: cb456 (1), si:dkey-221h15.3, wu:fc30c12, wu:fc33d01, wu:fc67g02 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have aspartate carbamoyltransferase activity and dihydroorotase activity. Involved in several processes, including 'de novo' pyrimidine nucleobase biosynthetic process; cranial nerve morphogenesis; and regulation of signal transduction. Predicted to localize to cytosol. Is expressed in several structures, including digestive system; immature eye; nervous system; neural tube; and pectoral fin. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 50. Orthologous to human CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase).
Genome Resources: Alliance (1),  Gene:266992 (1),  Ensembl(GRCz11):ENSDARG00000041895 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a52 Point Mutation Unknown Missense
  • Zebrafish International Resource Center (ZIRC) (order this)
  • hi2694Tg Transgenic Insertion Exon 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • hu10125 Point Mutation Unknown Missense ENU
    la013884Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la028268Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9368 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11882 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23778 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37121 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37122 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sl23 Small Deletion Exon 5 Frameshift, Premature Stop ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-cad N/A 1
    MO2-cad N/A 1
    MO3-cad N/A 2
    DISEASE ASSOCIATED WITH cad HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    early infantile epileptic encephalopathy 50 Alliance Epileptic encephalopathy, early infantile, 50 616457
    DISEASE ASSOCIATED WITH cad VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of vascular endothelial growth factor receptor signaling pathway (more)
    Cellular Component cytoplasm (more)
    Molecular Function amino acid binding (more)
    GO Terms (all 29)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cad-201 (1)    Ensembl 1454
    cad-203 (1)    Ensembl 7486
    ncRNA cad-004 (1)    Ensembl 525
    cad-005 (1)    Ensembl 791
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cad No data available
    MARKER RELATIONSHIPS
    cad Contained in: [BAC] DKEY-221H15 (1) (order this)
    cad Contains: [SNP] rs3729043 (1)
    cad Encodes: [EST] cb456 (1) (order this), fc30c12 (1), fc67g02
    cad Has Artifact: [cDNA] MGC:63627
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001009884 (1) 6937 nt
    Genomic GenBank:BX511178 (1) 187362 nt
    Select Tool
    Polypeptide UniProtKB:Q5XLV0 (1) 2230 aa
    Sequence Information (all 25)
    ORTHOLOGY for cad ( Chr: 20 )
    CITATIONS (52)