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ZIRC
ZFIN ID: ZDB-GENE-020424-3
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Gene Name: lamin A
Gene Symbol: lmna
Sequence Ontology ID : SO:0001217

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Previous Names: cb948 (1), wu:fk66d12 (1)

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(Including Attributions)
Location: Chr: 16 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have structural molecule activity. Involved in heart contraction and regulation of cell aging. Predicted to localize to the intermediate filament. Human ortholog(s) of this gene  ...
GENE EXPRESSION
All Expression Data: 13 figures from 5 publications
Directly Submitted Expression Data: 5 figures (11 images) from Thisse et al., 2001 [cb948]
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hsi9 Complex Unknown Unknown CRISPR
la027723Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa10537 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa13189 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa22872 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • Targeting reagents:
    PHENOTYPE
    Data: 6 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH lmna HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    autosomal dominant Emery-Dreifuss muscular dystrophy 2 Emery-Dreifuss muscular dystrophy 2, autosomal dominant 181350
    autosomal recessive Emery-Dreifuss muscular dystrophy 3 Emery-Dreifuss muscular dystrophy 3, autosomal recessive 616516
    Charcot-Marie-Tooth disease type 2B1 Charcot-Marie-Tooth disease, type 2B1 605588
    congenital muscular dystrophy due to LMNA mutation Muscular dystrophy, congenital 613205
    dilated cardiomyopathy 1A Cardiomyopathy, dilated, 1A 115200
    familial partial lipodystrophy type 2 Lipodystrophy, familial partial, type 2 151660
    lethal restrictive dermopathy Restrictive dermopathy, lethal 275210
    progeria Hutchinson-Gilford progeria 176670
    Heart-hand syndrome, Slovenian type 610140
    Malouf syndrome 212112
    Mandibuloacral dysplasia 248370
    DISEASE ASSOCIATED WITH lmna VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process heart contraction (more)
    Cellular Component intermediate filament (more)
    GO Terms (all 3)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001322 (1)
  • InterPro:IPR018039 (1)
  • InterPro:IPR036415 (1)
  • InterPro:IPR039008 (1)
  • InterPro:IPR042180 (1)
  • PROSITE:PS00226 (1)
  • PROSITE:PS51841 (1)
  • PROSITE:PS51842 (1)
  • Pfam:PF00038 (1)
  • Pfam:PF00932 (1)
    • TRANSCRIPTS
    Type Name Length (bp) Analysis
    ncRNA lmna-002 (1) 688
    Select Tool
    lmna-003 (1) 412
    Select Tool
    mRNA lmna-202 (1) 4620
    Select Tool
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lmna
    MARKER RELATIONSHIPS
    lmna Contained in: [BAC] DKEY-181C1 (1) (order this)
    lmna Encodes: [EST] cb948 (1) (order this), fk66d12 (1), wz10
    [cDNA] MGC:195196 (1) (order this), MGC:195205 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_152971 (1) 2078 bp
    Select Tool
    Genomic GenBank:CR848742 (1) 177769 bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8QPG3 (1) 675 aa
    Select Tool
    Sequence Clusters UniGene:10311 (1)
    Sequence Information (all 30)
    OTHER lmna GENE PAGES
  • Alliance (1)
  • Gene:195815 (1)
  • VEGA:OTTDARG00000021090 (1)
  • Ensembl(GRCz11):ENSDARG00000013415 (2)
    • ORTHOLOGY for lmna ( Chr: 16 )
    CITATIONS (42)