FIGURE

FIGURE 7

ID

ZDB-FIG-230606-12

Publication

Rodenas et al., 2023 - Venetoclax is a potent hepsin inhibitor that reduces the metastatic and prothrombotic phenotypes of hepsin-expressing colorectal cancer cells

Other Figures

All Figure Page

Back to All Figure Page

FIGURE 7

Venetoclax reduces Caco-2-HPN cell invasion in zebrafish larvae. (A) Experimental design of the zebrafish larvae xenotransplantation experiments and representative pictures of no invaded and invaded larvae showing red-labelled Caco-2 cells at the injection site (arrow) and several invasion foci (arrowheads). (B) Evaluation of invasion score 3 days after injection in the yolk sac of 2-dpf casper zebrafish larvae. The results showed are a pool of three different experiments. dpf, days post-fertilization; ***: p-value < 0.001; n, number of larvae per treatment; CACO WT, Caco-2 cells with hepsin basal expression; CACO HPN, Caco-2 cells overexpressing hepsin; HPN + V, Caco-2 cells overexpressing hepsin pretreated with venetoclax.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Mol Biosci