FIGURE

FIGURE 5

ID

ZDB-FIG-230606-10

Publication

Rodenas et al., 2023 - Venetoclax is a potent hepsin inhibitor that reduces the metastatic and prothrombotic phenotypes of hepsin-expressing colorectal cancer cells

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FIGURE 5

Effects of hepsin levels on thrombin generation by Caco-2 and Caco-2-HPN cells. Thrombin generation was performed after incubation of plasma with cells for 3 h as described in Materials and Methods. Afterwards, plasma was incubated with PPP reagent ^® (final concentrations: tissue factor, 1 pmol/L; phospholipids, 4 μmol/L) and calcium chloride. The lag time (min) (A), time to peak (min) (B), endogenous thrombin potential (ETP, nmol*min) (C), thrombin peak (peak, nmol) (D), and mean rate index (Velocity, nmol/min) (E) were recorded. The data represent the mean ± standard error of the mean of at least six separate experiments. Caco-2-HPN, Caco-2 cells overexpressing hepsin; Caco-2, Caco-2 cells with hepsin basal expression; *: p-value < 0.05.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Mol Biosci