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Fig. 2

ID

ZDB-FIG-220726-2

Publication

Hattab et al., 2022 - Pseudomonas Synergizes with Fluconazole against Candida during Treatment of Polymicrobial Infection

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Fig. 2

FIG 2 Fluconazole is synergistic with P. aeruginosa against C. albicans during mucosal infection. (A–E) Fish were infected in the swimbladder with either 50–100 C. albicans (mono-infection) or with 25–50 C. albicans and 25–50 P. aeruginosa, screened for fungal inoculum, then reared in water with or without 100 μg/mL FLC. (A) FLC-treatment increases survival during co-infection. Data pooled from 13 independent experiments. (B) Representative images of swimbladder infected with C. albicans or C. albicans + P. aeruginosa with or without FLC (100 μg/mL). Scale bars = 100 μm. Dotted white lines mark the boundary of the swimbladder. (C) C. albicans burden was measured by analysis of confocal z-stacks and calculation of square pixel coverage area. Graphs show medians and 95% confidence intervals. Data from 13 independent experiments. (D) Fraction of fungi surviving FLC treatment. Results are from 5 independent experiments. Monte-Carlo analysis was used to compare groups. (E) C. albicans burden calculated by CFU. Data from 5 independent experiments. (p > 0.05 NS; < 0.05 *; <0.01 **; <0.001 ***; <0.0001 ****).

Expression Data

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Antibody Labeling

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