FIGURE

Fig. 5

ID

ZDB-FIG-220701-48

Publication

Oliveira et al., 2022 - Mutant IL7R collaborates with MYC to induce T-cell acute lymphoblastic leukemia

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Fig. 5

Mutant IL7R increases leukemia propagating potential in Myc-induced leukemias.

a CG1-strain fish injected at the one-cell stage with either rag2:Myc alone or with rag2:IL7R^mut2. Animals were also co-injected with rag2:mCherry or rag2:GFP to visualize leukemia onset and progression, respectively. Representative images of transgenic mosaic zebrafish at 44 and 39 dpf, respectively; Scale bar, 1 mm. b Kaplan–Meier analysis of disease progression (Gehan-Breslow-Wilcoxon test). Number of animals analyzed per genotype is shown in parenthesis. c Leukemia propagating cell (LPC) frequency was assessed using limiting dilution cell transplantation analysis and calculated using the ELDA software. Graph showing LPC frequency within Myc and Myc + IL7R^mut2 induced primary T-ALL. Each point represents a distinct primary leukemia generated in this manuscript (filled) and compared with LPC frequency from [38] and [39], denoted by X (Mann–Whitney test). In total, 16 of Myc-induced and 5 Myc + IL7R^mut2 T-ALLs were included in this analysis.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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