FIGURE
Fig. 4
- ID
- ZDB-FIG-220701-47
- Publication
- Oliveira et al., 2022 - Mutant IL7R collaborates with MYC to induce T-cell acute lymphoblastic leukemia
- Other Figures
- All Figure Page
- Back to All Figure Page
Fig. 4
Myc + IL7Rmut induced leukemias display IL-7R-mediated signaling upregulation and are polyclonal.
a Heatmap representation showing expression of well-known T- and B-cell associated genes, as well as common STAT5 target genes (adj. P < 0.05). b Transcriptome data integration and gene set enrichment analysis show a significant enrichment of the IL-2/STAT5 signaling hallmark gene set in Myc + IL7Rmut derived leukemias when compared with Myc derived leukemias. c TCR-β gene rearrangements in Myc + IL7Rmut vs Myc derived T-ALLs. Shown as dotplots and boxplots are the number of clonotypes of the TRB locus and the equitability value per sample, both based on productive rearrangements. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and
ZFIN has permission only to display this image to its users.
Additional permissions should be obtained from the applicable author or publisher of the image.
Full text @ Leukemia