FIGURE

Figure 3—figure supplement 1.

ID

ZDB-FIG-220522-16

Publication

Solman et al., 2022 - Inflammatory response in hematopoietic stem and progenitor cells triggered by activating SHP2 mutations evokes blood defects

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Figure 3—figure supplement 1.

Identification of different hematopoietic stem and progenitor cells (HSPCs) subpopulations based on differential expression of representative genes.

(A) Heat map showing scaled expression (log TPM [transcripts per million] values) of representative genes (y-axis) in all cells (x-axis). Cells belonging to distinct clusters are squared with a dashed line and cluster identity is indicated on the top of the heat map. Cluster 1 is characterized by expression of genes characteristic for thrombocyte and erythroid differentiation, such as gata1a and klf1. Cells from cluster 2 express typical hematopoietic stem cell markers, such as c-myb and her6 (HES1 analogue in human). Cells from cluster 3 express early myeloid progenitor markers, such as runx3 and cxcr4b. Cells from cluster 4 express genes typical for both monocyte and macrophages, such as marco and ctsba. (B) t-Distributed stochastic neighbor embedding (t-SNE) maps showing the sum of total read-counts of selected neutrophil-specific genes.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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