FIGURE

Fig 6

ID

ZDB-FIG-220415-24

Publication

Madelaine et al., 2020 - Genetic deciphering of the antagonistic activities of the melanin-concentrating hormone and melanocortin pathways in skin pigmentation

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Fig 6

MCH signaling counteracts melanocortin system activity to promote melanosome contraction in adult zebrafish.

(A-D) Loss of function phenotype on skin pigmentation from white adapted adult control (A), pomca(B), mchr2(C) or double mchr2; pomca(D) homozygous mutant. (E-G) Loss of function phenotype on skin pigmentation from black adapted adult control (E), pomca(F), mchr2(G) or double mchr2; pomca(H) homozygous mutant. Similar to the pomca homozygous mutant, pomca; mchr2 double homozygous mutant phenotype is characterized by melanosome contraction on a black background, indicating that pomca loss of function is sufficient to allow melanosome contraction in absence of MCH signaling in adult zebrafish. Lateral view (E-G).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mchr2b^{zf3415/zf3415} mchr2b^{zf3415/zf3415}; pomca^{zf3414/zf3414}
Observed In:	integument background adaptation melanocyte cellular pigment accumulation melanocyte melanosome melanocyte melanosome localization
Stage:	Adult

Phenotype Detail

Acknowledgments

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