FIGURE

Fig. 8

ID

ZDB-FIG-211011-23

Publication

Wobus et al., 2021 - Luspatercept restores SDF-1-mediated hematopoietic support by MDS-derived mesenchymal stromal cells

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Fig. 8

High GDF-11 levels in the MDS BMME activate Smad2/3 phosphorylation and expression of Co-Smad4 that binds to the SDF-1 promoter region [7] thereby suppressing transcription and leading to impaired hematopoiesis. Trapping GDF-11 by RAP-536/luspatercept reduces Smad2/3 and Smad4 activity resulting in SDF-1 promoter activation and elevated expression, thereby restoring HSPC support.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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