FIGURE

Fig. 2

ID

ZDB-FIG-211011-17

Publication

Wobus et al., 2021 - Luspatercept restores SDF-1-mediated hematopoietic support by MDS-derived mesenchymal stromal cells

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Fig. 2

A After 1 week of co-culturing HSPCs derived from healthy donors on GDF-11/RAP-536 pre-treated MDS MSC layers, the fold change of CD45+ cell numbers compared to the untreated control layers was determined in the supernatant and the adherent fraction under the indicated treatment conditions. Error bars represent mean ± SD of the adherent fraction, ns p > 0.05, **p < 0.01, ***p < 0.001, and the supernatant fraction, ns p > 0.05, ⁺⁺p < 0.01, N = 5, analyzed by two-way ANOVA with Tukey’s multiple comparisons test. B The migratory capacity of co-culture-derived HSPCs was analyzed in a Boyden chamber trans-well system. Error bars represent mean ± SD. ns p > 0.05, **p < 0.01, ***p < 0.001, N = 3 different co-culture experiments. Significance was assessed by one-way ANOVA with Tukey’s multiple comparisons test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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