FIGURE

Figure 8

ID

ZDB-FIG-210911-19

Publication

Ear et al., 2021 - A long isoform of GIV/Girdin contains a PDZ-binding module that regulates localization and G-protein binding

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Figure 8

GIV-L is preferentially expressed in the surface epithelium of colon crypts and is downregulated in the transformed epithelium in colon polyps.A and B, images representative of patterns of GIV staining, as determined by immunohistochemistry staining on normal healthy human colon (A) and matched adjacent adenoma (B) with various GIV (total and isoform specific) antibodies. See also Figure S3 for validation studies on the antibodies. C, schematic summarizing the observed expression pattern observed in panels A (top) and B (bottom). ↑, ↓ and ↔ indicate upregulation, downregulation, and no discernible changes in expression, respectively. D and E, working model of the opposing roles (D) and patterns of altered expression (E) of GIV and GIV-L isoforms in the colonic epithelium. Cytosolic GIV promotes stemness, growth, survival, and cell migration, whereas cell-junction-localized GIV-L inhibits growth, survival cell cycle, cell death.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Biol. Chem.