FIGURE

Figure 2

ID

ZDB-FIG-200713-12

Publication

Angileri et al., 2020 - dnmt1 function is required to maintain retinal stem cells within the ciliary marginal zone of the zebrafish eye

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Figure 2

Cell death is elevated in the dnmt1^−/− CMZ. A–F dnmt1 sibling (A–C) and mutant (D–F) retinae labeled with DAPI (gray; nuclei) and TUNEL (magenta; dsDNA breaks) from 3 to 5dpf. G–J Proportion of retinal layers (GCL, INL, ONL, and CMZ) labeled by TUNEL staining. K Proportion of TUNEL⁺ cells within each layer from 3 to 5dpf. L–N Average number of TUNEL⁺ cells in each retinal layer of siblings and dnmt1^−/− larvae from 3 to 5dpf. Yellow arrows in A–F indicate TUNEL⁺ nuclei. Scale bars = 30 µm. *p < 0.05, **p < 0.005, ***p < 0.0005, ****p < 0.00005. Dorsal is up in all images.

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

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