ZFIN Figure: El-Brolosy et al., 2019, Fig. 2

ZFIN ID: ZDB-FIG-191227-10

ZFIN ID: ZDB-FIG-191227-10

El-Brolosy et al., 2019 - Genetic compensation triggered by mutant mRNA degradation. Nature 568(7751):193-197 Full text @ Nature

ADDITIONAL FIGURES

EXPRESSION / LABELING:

Genes:	hbegfb vclb vegfab
Fish:	hbegfa^{bns189/bns189} vcla^{bns241/bns241} vegfaa^{bns301/bns301} hbegfa^{bns189/bns189}; upf1^{ya3319/ya3319} vcla^{bns241/bns241}; upf1^{ya3319/ya3319} vegfaa^{bns301/bns301}; upf1^{ya3319/ya3319}
Anatomical Term:	whole organism
Stage Range:	26+ somites to Protruding-mouth

PHENOTYPE:

Fish:	hbegfa^{bns189/bns189} vcla^{bns241/bns241} vegfaa^{bns301/bns301} hbegfa^{bns189/bns189}; upf1^{ya3319/ya3319} vcla^{bns241/bns241}; upf1^{ya3319/ya3319} vegfaa^{bns301/bns301}; upf1^{ya3319/ya3319}
Observed In:	whole organism
Stage Range:	26+ somites to Protruding-mouth

Fig. 2 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details

Gene	Fish	Conditions	Stage	Anatomy	Assay
hbegfb	hbegfa^{bns189/bns189}	standard conditions	Protruding-mouth	whole organism	RTPCR
	hbegfa^{bns189/bns189}; upf1^{ya3319/ya3319}	standard conditions	Protruding-mouth	whole organism	RTPCR
vclb	vcla^{bns241/bns241}	standard conditions	Prim-5	whole organism	RTPCR
	vcla^{bns241/bns241}; upf1^{ya3319/ya3319}	standard conditions	Prim-5	whole organism	RTPCR
vegfab	vegfaa^{bns301/bns301}	standard conditions	26+ somites	whole organism	RTPCR
	vegfaa^{bns301/bns301}; upf1^{ya3319/ya3319}	standard conditions	26+ somites	whole organism	RTPCR

Antibody Labeling Details No data available

Phenotype Details

Fish	Conditions	Stage	Phenotype
hbegfa^{bns189/bns189}	standard conditions	Protruding-mouth	whole organism hbegfb expression increased amount, abnormal
hbegfa^{bns189/bns189}; upf1^{ya3319/ya3319}	standard conditions	Protruding-mouth	whole organism hbegfb expression amount, ameliorated
vcla^{bns241/bns241}	standard conditions	Prim-5	whole organism vclb expression increased amount, abnormal
vcla^{bns241/bns241}; upf1^{ya3319/ya3319}	standard conditions	Prim-5	whole organism vclb expression amount, ameliorated
vegfaa^{bns301/bns301}	standard conditions	26+ somites	whole organism vegfab expression increased amount, abnormal
vegfaa^{bns301/bns301}; upf1^{ya3319/ya3319}	standard conditions	26+ somites	whole organism vegfab expression amount, ameliorated

Full text @ Nature