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Gene

vegfab

ID
ZDB-GENE-030131-4605
Name
vascular endothelial growth factor Ab
Symbol
vegfab Nomenclature History
Previous Names
  • fd42e02 (1)
  • si:dkey-14d8.3
  • wu:fd42e02
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to enable chemoattractant activity; growth factor activity; and vascular endothelial growth factor receptor 1 binding activity. Involved in phosphorylation. Acts upstream of or within sprouting angiogenesis. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular space. Is expressed in nervous system; pronephros; and vasculature. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); hypertension (multiple); and reproductive organ cancer (multiple). Orthologous to human VEGFA (vascular endothelial growth factor A).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
21 figures from 18 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With vegfab Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{Microvascular complications of diabetes 1} 603933
Associated With vegfab Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR023581 Platelet-derived growth factor, conserved site
Domain IPR000072 PDGF/VEGF domain
Domain IPR027928 Vascular endothelial growth factor, heparin-binding domain
Homologous_superfamily IPR029034 Cystine-knot cytokine
Homologous_superfamily IPR036841 Vascular endothelial growth factor, heparin-binding domain superfamily
Domain Details Per Protein
Protein Length Cystine-knot cytokine PDGF/VEGF domain Platelet-derived growth factor, conserved site Vascular endothelial growth factor, heparin-binding domain Vascular endothelial growth factor, heparin-binding domain superfamily
UniProtKB:A4VCG6 194
UniProtKB:F1QDN7 251
UniProtKB:F1QTG5 146
UniProtKB:Q0QYI0 194
UniProtKB:Q1ECU5 250
UniProtKB:Q1ANK8 233
UniProtKB:Q5RHW5 228
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations