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ZIRC
ZFIN ID: ZDB-FIG-171016-5
Damm et al., 2017 - Pdgf signalling guides neural crest contribution to the haematopoietic stem cell specification niche. Nature cell biology   19(5):457-467 Full text @ Nat. Cell Biol.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Knockdown Reagent:
Anatomical Terms:
Stage Range: Prim-5 to Day 4
PHENOTYPE:
Fish:
Knockdown Reagent:
Observed In:
Stage Range: Prim-5 to Day 4

Fig. 3 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
crestin WIK control Prim-5 migratory neural crest ISH
WIK + MO1-pdgfra control Prim-5 migratory neural crest ISH
pdgfrab1059/+ control Prim-5 migratory neural crest ISH
pdgfrab1059/b1059 control Prim-5 migratory neural crest ISH
EGFP s896Tg; zf169Tg control Prim-25 dorsal aorta IHC
Prim-25 hematopoietic stem cell IHC
s896Tg; zf169Tg + MO1-pdgfra control Prim-25 dorsal aorta IHC
Prim-25 hematopoietic stem cell IHC
mCherry s896Tg; zf169Tg control Prim-25 dorsal aorta IHC
Prim-25 hematopoietic stem cell IHC
s896Tg; zf169Tg + MO1-pdgfra control Prim-25 dorsal aorta IHC
Prim-25 hematopoietic stem cell IHC
myb WIK control Prim-15 hematopoietic multipotent progenitor cell ISH
WIK + MO1-pdgfra control Prim-15 hematopoietic multipotent progenitor cell ISH
pdgfrab1059/+ control Prim-15 hematopoietic multipotent progenitor cell ISH
pdgfrab1059/b1059 control Prim-15 hematopoietic multipotent progenitor cell ISH
rag1 WIK control Day 4 T cell ISH
WIK + MO1-pdgfra control Day 4 T cell ISH
Day 4 thymus ISH
pdgfrab1059/+ control Day 4 T cell ISH
pdgfrab1059/b1059 control Day 4 T cell ISH
Day 4 thymus ISH
runx1 WIK control Prim-5 hematopoietic multipotent progenitor cell ISH
WIK + MO1-pdgfra control Prim-5 hematopoietic multipotent progenitor cell ISH
pdgfrab1059/+ control Prim-5 hematopoietic multipotent progenitor cell ISH
pdgfrab1059/b1059 control Prim-5 hematopoietic multipotent progenitor cell ISH
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
WIK + MO1-pdgfra control Prim-5 hematopoietic multipotent progenitor cell runx1 expression decreased amount, abnormal
Prim-5 hematopoietic multipotent progenitor cell decreased amount, abnormal
Prim-5 hematopoietic progenitor cell differentiation decreased occurrence, abnormal
Prim-5 trunk neural crest cell migration arrested, abnormal
Prim-15 hematopoietic multipotent progenitor cell myb expression decreased amount, abnormal
Prim-15 hematopoietic multipotent progenitor cell decreased amount, abnormal
Prim-15 hematopoietic progenitor cell differentiation decreased occurrence, abnormal
Day 4 T cell decreased amount, abnormal
Day 4 thymus rag1 expression decreased amount, abnormal
pdgfrab1059/b1059 control Prim-5 hematopoietic multipotent progenitor cell decreased amount, abnormal
Prim-5 hematopoietic multipotent progenitor cell runx1 expression decreased amount, abnormal
Prim-5 hematopoietic progenitor cell differentiation decreased occurrence, abnormal
Prim-5 trunk neural crest cell migration arrested, abnormal
Prim-15 hematopoietic multipotent progenitor cell decreased amount, abnormal
Prim-15 hematopoietic multipotent progenitor cell myb expression decreased amount, abnormal
Prim-15 hematopoietic progenitor cell differentiation decreased occurrence, abnormal
Day 4 T cell decreased amount, abnormal
Day 4 thymus rag1 expression decreased amount, abnormal
s896Tg; zf169Tg + MO1-pdgfra control Prim-25 hematopoietic stem cell decreased amount, abnormal
Full text @ Nat. Cell Biol.