ZFIN Gene: runx1

ZFIN ID: ZDB-GENE-000605-1

ZFIN ID: ZDB-GENE-000605-1

Gene Name:

RUNX family transcription factor 1

Gene Symbol:

runx1

Sequence Ontology ID :

SO:0000704

Previous Names:

runx1a (1), runxa, aml1 (1)

Location:

Chr: 1 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Exhibits sequence-specific DNA binding activity. Involved in several processes, including endothelial to hematopoietic transition; hemopoiesis; and positive regulation of neutrophil differentiation. ...

GENE EXPRESSION
All Expression Data:	312 figures from 148 publications
Wild-type Stages, Structures:	Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
	angioblastic mesenchymal cell anterior lateral mesoderm anterior lateral plate mesoderm blood blood cell blood island hematopoietic stem cell blood island blood vessel endothelial cell caudal artery caudal hematopoietic tissue hematopoietic multipotent progenitor cell common myeloid progenitor cranial ganglion dermis dorsal aorta hematopoietic multipotent progenitor cell dorsal aorta hematopoietic stem cell dorsal aorta endothelial cell erythroid lineage cell facial ganglion glossopharyngeal ganglion head hematopoietic cell hematopoietic multipotent progenitor cell hematopoietic stem cell hematopoietic system intermediate cell mass of mesoderm hematopoietic stem cell intermediate cell mass of mesoderm hematopoietic system intermediate cell mass of mesoderm presumptive blood intermediate cell mass of mesoderm kidney lateral mesoderm lateral plate mesoderm myeloid cell myeloid leukocyte neuron nucleate erythrocyte olfactory epithelium olfactory placode opercle pharyngeal epithelium post-vent region hematopoietic cell post-vent vasculature posterior lateral mesoderm posterior lateral plate mesoderm retinal ganglion cell layer Rohon-Beard neuron rostral blood island tail bud trunk trunk vasculature unspecified vagal ganglion ventral mesoderm ventral wall of dorsal aorta anatomical region ventral wall of dorsal aorta endothelial cell ventral wall of dorsal aorta hematopoietic multipotent progenitor cell ventral wall of dorsal aorta hematopoietic stem cell ventral wall of dorsal aorta whole organism
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
hg1	Point Mutation	Exon 4	Premature Stop	ENU
zko52a	Small Deletion	Unknown	Unknown	CRISPR	China Zebrafish Resource Center (CZRC) (order this)

Targeting reagents:

PHENOTYPE

Data:

26 figures from 16 publications

Observed in:

DISEASE ASSOCIATED WITH runx1 HUMAN ORTHOLOG

Disease Ontology Term	OMIM Term	OMIM Phenotype ID
acute myeloid leukemia	Leukemia, acute myeloid	601626
	Platelet disorder, familial, with associated myeloid malignancy	601399

DISEASE ASSOCIATED WITH runx1 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	myeloid cell differentiation (more)
Cellular Component	nucleus (more)
Molecular Function	sequence-specific DNA binding (more)

GO Terms (all 24)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR000040 (1) InterPro:IPR008967 (1) InterPro:IPR012346 (1) InterPro:IPR013524 (1) InterPro:IPR013711 (1) InterPro:IPR016554 (1) InterPro:IPR027384 (1)	PROSITE:PS51062 (1)	Pfam:PF00853 (1) Pfam:PF08504 (1)

TRANSCRIPTS No data available

GENE PRODUCT DESCRIPTION

INTERACTIONS AND PATHWAYS

ANTIBODIESNo data available

PLASMIDSNo data available

CONSTRUCTS WITH SEQUENCES FROM runx1

MARKER RELATIONSHIPSNo data available

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_131603 (1)	2543bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CABZ01057246 (1)	10349bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl
Polypeptide	UniProtKB:Q9DGB8 (1)	451aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:82592 (1)

Sequence Information (all 18)

OTHER runx1 GENE PAGES

Alliance (1)

Gene:58126 (1)

Ensembl(GRCz11):ENSDARG00000087646 (1)

ORTHOLOGY for runx1 (Chr: 1)

CITATIONS (237)

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