| ZFIN ID: ZDB-GENE-000605-1 |
| Gene Name: | RUNX family transcription factor 1 | |||||||||||||
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| Gene Symbol: | runx1 Nomenclature History |
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| Previous Names: | runx1a (1), runxa, aml1 (1) | |||||||||||||
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| Gene Type: | protein_coding_gene | |||||||||||||
| Location: | Chr: 1 Mapping Details/Browsers | |||||||||||||
| Description: | Exhibits sequence-specific DNA binding activity. Involved in several processes, including endothelial to hematopoietic transition; hemopoiesis; and positive regulation of neutrophil differentiation. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in Alzheimer's disease; asthma; hematologic cancer (multiple); and rheumatoid arthritis. Is expressed in several structures, including cranial ganglion; hematopoietic cell; hematopoietic system; mesoderm; and vasculature. Orthologous to human RUNX1 (RUNX family transcription factor 1). | |||||||||||||
| Genome Resources: | Alliance (1), Gene:58126 (1), Ensembl(GRCz11):ENSDARG00000087646 (1) | |||||||||||||
| Allele | Type | Localization | Consequence | Mutagen | Suppliers |
|---|---|---|---|---|---|
| hg1 | Point Mutation | Exon 4 | Premature Stop | ENU | |
| zko52a | Small Deletion | Unknown | Unknown | CRISPR |
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| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
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| acute myeloid leukemia | Alliance | Leukemia, acute myeloid | 601626 |
| Platelet disorder, familial, with associated myeloid malignancy | 601399 |
| Ontology | GO Term |
|---|---|
| Biological Process | myeloid cell differentiation (more) |
| Cellular Component | nucleus (more) |
| Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding (more) |
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| Construct | Regulatory Regions | Coding Sequences | Species | Tg Lines | Publications |
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| Tg(hsp70l:MYC-runx1) | hsp70l | runx1 | Danio rerio | 1 | 3 |
| Tg(hsp70l:runx1) | hsp70l | runx1 | Danio rerio | 1 | 1 |
| Tg(runx1:EGFP) | runx1 | EGFP | Danio rerio | 1 | 1 |
| tg(runx1:gfp) | runx1 | GFP | Danio rerio | 1 | 1 |
| Tg(runx1P1:EGFP) | runx1 | EGFP | Danio rerio | 1 | 6 |
| tg(runx1p2:amcyan) | runx1 | AmCyan | Danio rerio | 1 | 1 |
| Tg(runx1P2:EGFP) | runx1 | EGFP | Danio rerio | 1 | 10 |
| Type | Accession # | Length (bp/aa) | Analysis |
|---|---|---|---|
| RNA | RefSeq:NM_131603 (1) | 2543 bp |
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| Genomic | GenBank:CABZ01057246 (1) | 10349 bp |
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| Polypeptide | UniProtKB:Q9DGB8 (1) | 451 aa |
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| Sequence Clusters | UniGene:82592 (1) |
