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ZIRC
ZFIN ID: ZDB-GENE-000605-1
Gene Name: RUNX family transcription factor 1
Gene Symbol: runx1    Nomenclature History

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Previous Names: runx1a (1), runxa, aml1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Exhibits sequence-specific DNA binding activity. Involved in several processes, including endothelial to hematopoietic transition; hemopoiesis; and positive regulation of neutrophil differentiation. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in Alzheimer's disease; asthma; hematologic cancer (multiple); and rheumatoid arthritis. Is expressed in several structures, including cranial ganglion; hematopoietic cell; hematopoietic system; mesoderm; and vasculature. Orthologous to human RUNX1 (RUNX family transcription factor 1).
Genome Resources: Alliance (1),  Gene:58126 (1),  Ensembl(GRCz11):ENSDARG00000087646 (1)
GENE EXPRESSION
All Expression Data: 314 figures from 150 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hg1 Point Mutation Exon 4 Premature Stop ENU
zko52a Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-runx1 1
    MO1-runx1 N/A 11
    MO2-runx1 N/A 4
    MO3-runx1 N/A 4
    MO4-runx1 N/A 3
    MO5-runx1 N/A 1
    MO6-runx1 N/A 3
    MO7-runx1 N/A 1
    MO8-runx1 N/A 1
    MO9-runx1 N/A 4
    DISEASE ASSOCIATED WITH runx1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    acute myeloid leukemia Alliance Leukemia, acute myeloid 601626
    Platelet disorder, familial, with associated myeloid malignancy 601399
    DISEASE ASSOCIATED WITH runx1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process myeloid cell differentiation (more)
    Cellular Component nucleus (more)
    Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding (more)
    GO Terms (all 28)
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM runx1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:MYC-runx1) hsp70l runx1 Danio rerio 1 3
    Tg(hsp70l:runx1) hsp70l runx1 Danio rerio 1 1
    Tg(runx1:EGFP) runx1 EGFP Danio rerio 1 1
    tg(runx1:gfp) runx1 GFP Danio rerio 1 1
    Tg(runx1P1:EGFP) runx1 EGFP Danio rerio 1 6
    tg(runx1p2:amcyan) runx1 AmCyan Danio rerio 1 1
    Tg(runx1P2:EGFP) runx1 EGFP Danio rerio 1 10
    MARKER RELATIONSHIPS No data available
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131603 (1) 2543 bp
    Genomic GenBank:CABZ01057246 (1) 10349 bp
    Polypeptide UniProtKB:Q9DGB8 (1) 451 aa
    Sequence Clusters UniGene:82592 (1)
    Sequence Information (all 18)
    ORTHOLOGY for runx1 ( Chr: 1 )
    CITATIONS (243)