ZFIN Gene: runx1

ZFIN ID: ZDB-GENE-000605-1

ZFIN ID: ZDB-GENE-000605-1

Gene Name:

RUNX family transcription factor 1

Gene Symbol:

runx1 Nomenclature History

Previous Names:

runx1a (1), runxa, aml1 (1)

Gene Type:

protein_coding_gene

Location:

Chr: 1 Mapping Details/Browsers

Description:

Exhibits RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including endothelial to hematopoietic transition; hemopoiesis; and positive regulation of neutrophil differentiation. Predicted to localize to nucleus. Is expressed in several structures, including cranial ganglion; hematopoietic cell; hematopoietic system; mesoderm; and vasculature. Human ortholog(s) of this gene implicated in Alzheimer's disease; asthma; hematologic cancer (multiple); and rheumatoid arthritis. Orthologous to human RUNX1 (RUNX family transcription factor 1).

Genome Resources:

Alliance (1), Gene:58126 (1), Ensembl(GRCz11):ENSDARG00000087646 (1)

GENE EXPRESSION
All Expression Data:	327 figures from 155 publications
Wild-type Stages, Structures:	Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
	angioblastic mesenchymal cell anterior lateral mesoderm anterior lateral plate mesoderm blood blood cell blood island hematopoietic stem cell blood island blood vessel endothelial cell caudal artery caudal hematopoietic tissue hematopoietic multipotent progenitor cell common myeloid progenitor cranial ganglion dermis dorsal aorta hematopoietic multipotent progenitor cell dorsal aorta hematopoietic stem cell dorsal aorta endothelial cell erythroid lineage cell facial ganglion glossopharyngeal ganglion head hematopoietic cell hematopoietic multipotent progenitor cell hematopoietic stem cell hematopoietic system intermediate cell mass of mesoderm hematopoietic stem cell intermediate cell mass of mesoderm hematopoietic system intermediate cell mass of mesoderm presumptive blood intermediate cell mass of mesoderm kidney lateral mesoderm lateral plate mesoderm myeloid cell myeloid leukocyte neuron nucleate erythrocyte olfactory epithelium olfactory placode opercle pharyngeal epithelium post-vent region hematopoietic cell post-vent vasculature posterior lateral mesoderm posterior lateral plate mesoderm retinal ganglion cell layer Rohon-Beard neuron rostral blood island tail bud trunk trunk vasculature unspecified vagal ganglion ventral mesoderm ventral wall of dorsal aorta anatomical region ventral wall of dorsal aorta angioblastic mesenchymal cell ventral wall of dorsal aorta endothelial cell ventral wall of dorsal aorta hematopoietic multipotent progenitor cell ventral wall of dorsal aorta hematopoietic stem cell ventral wall of dorsal aorta whole organism
High Throughput Expression:	GEO (1) , Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
hg1	Point Mutation	Exon 4	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)
zko52a	Small Deletion	Unknown	Unknown	CRISPR	China Zebrafish Resource Center (CZRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
CRISPR1-runx1	zko52a	1
MO1-runx1	N/A	12
MO2-runx1	N/A	5
MO3-runx1	N/A	5
MO4-runx1	N/A	3
MO5-runx1	N/A	1
MO6-runx1	N/A	3
MO7-runx1	N/A	1
MO8-runx1	N/A	1
MO9-runx1	N/A	4

PHENOTYPE

Data:

26 figures from 16 publications

Observed in:

DISEASE ASSOCIATED WITH runx1 HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
acute myeloid leukemia	Alliance	Leukemia, acute myeloid	601626
		Platelet disorder, familial, with associated myeloid malignancy	601399

DISEASE ASSOCIATED WITH runx1 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	myeloid cell differentiation (more)
Cellular Component	nucleus (more)
Molecular Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding (more)

GO Terms (all 28)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS No data available

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM runx1

Construct	Regulatory Regions	Coding Sequences	Species	Tg Lines	Publications
Tg(hsp70l:MYC-runx1)	hsp70l	runx1	Danio rerio	1	3
Tg(hsp70l:runx1)	hsp70l	runx1	Danio rerio	1	1
Tg(runx1:EGFP)	runx1	EGFP	Danio rerio	1	1
tg(runx1:gfp)	runx1	GFP	Danio rerio	1	1
Tg(runx1P1:EGFP)	runx1	EGFP	Danio rerio	1	6
tg(runx1p2:amcyan)	runx1	AmCyan	Danio rerio	1	1
Tg(runx1P2:EGFP)	runx1	EGFP	Danio rerio	1	10

MARKER RELATIONSHIPS No data available

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_131603 (1)	2543 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CABZ01057246 (1)	10349 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl
Polypeptide	UniProtKB:Q9DGB8 (1)	451 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 17)

ORTHOLOGY for runx1 ( Chr: 1 )

CITATIONS (253)

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