Gene
runx1
- ID
- ZDB-GENE-000605-1
- Name
- RUNX family transcription factor 1
- Symbol
- runx1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cardiac muscle tissue regeneration; positive regulation of collagen biosynthetic process; and regulation of connective tissue replacement. Acts upstream of or within several processes, including endothelial to hematopoietic transition; hemopoiesis; and regulation of gene expression. Predicted to be located in nucleus. Is expressed in several structures, including cranial ganglion; hematopoietic cell; hematopoietic system; mesoderm; and vasculature. Human ortholog(s) of this gene implicated in acute myeloid leukemia and esophagus squamous cell carcinoma. Orthologous to human RUNX1 (RUNX family transcription factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 379 figures from 178 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 32 figures from 19 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute myeloid leukemia | Alliance | Leukemia, acute myeloid | 601626 |
| Platelet disorder, familial, with associated myeloid malignancy | 601399 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR013524 | Runt domain |
| Domain | IPR013711 | Runx, C-terminal domain |
| Family | IPR000040 | Acute myeloid leukemia 1 protein (AML1)/Runt |
| Family | IPR016554 | Runt-related transcription factor RUNX |
| Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding |
| Homologous_superfamily | IPR012346 | p53/RUNT-type transcription factor, DNA-binding domain superfamily |
| Homologous_superfamily | IPR027384 | Runx, central domain superfamily |
Domain Details Per Protein
| Protein | Length | Acute myeloid leukemia 1 protein (AML1)/Runt | p53-like transcription factor, DNA-binding | p53/RUNT-type transcription factor, DNA-binding domain superfamily | Runt domain | Runt-related transcription factor RUNX | Runx, central domain superfamily | Runx, C-terminal domain |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q9DGB8
|
451 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available