ZFIN ID: ZDB-FIG-170630-16
Costa et al., 2017 - Perturbations in cell signaling elicit early cardiac defects in mucopolysaccharidosis type II. Human molecular genetics   26(9):1643-1655 Full text @ Hum. Mol. Genet.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Condition:
Knockdown Reagent:
Anatomical Terms:
Stage Range: Protruding-mouth to Day 6
PHENOTYPE:
Fish:
Condition:
Knockdown Reagent:
Observed In:
Stage: Day 5

Fig. 5 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
EGFP el108Tg control Day 5 trabecular layer of ventricle IFL
el108Tg chemical treatment by environment: purmorphamine Day 5 trabecular layer of ventricle IFL
el108Tg + MO1-ids standard conditions Day 5 trabecular layer of ventricle IFL
el108Tg + MO1-ids chemical treatment by environment: purmorphamine Day 5 heart IFL
Day 5 trabecular layer of ventricle IFL
ia10Tg ; el108Tg standard conditions Protruding-mouth cardiac muscle IFL
Day 6 cardiac muscle IFL
mCherry ia10Tg ; el108Tg standard conditions Protruding-mouth cardiac muscle cell nucleus ISH
Day 6 cardiac muscle cell nucleus ISH
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
el108Tg chemical treatment by environment: purmorphamine Day 5 trabecular layer of ventricle size, normal
el108Tg + MO1-ids standard conditions Day 5 cardiac ventricle heart trabecula formation disrupted, abnormal
Day 5 heart rudiment smoothened signaling pathway disrupted, abnormal
Day 5 smoothened signaling pathway decreased process quality, abnormal
Day 5 trabecular layer of ventricle decreased size, abnormal
el108Tg + MO1-ids chemical treatment by environment: purmorphamine Day 5 cardiac ventricle heart trabecula formation disrupted, ameliorated
Day 5 trabecular layer of ventricle decreased size, ameliorated
Full text @ Hum. Mol. Genet.