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ZIRC
ZFIN ID: ZDB-FIG-170210-3
Wang et al., 2016 - The somite-secreted factor Maeg promotes zebrafish embryonic angiogenesis. Oncotarget   7(47):77749-77763 Full text @ Oncotarget
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Gene:
Fish:
Knockdown Reagent:
Anatomical Terms:
Stage: Prim-15
PHENOTYPE:
Fish:
Knockdown Reagent:
Observed In:
Stage Range: Prim-5 to Prim-15

Fig. 3

maeg loss of function results in the blood vessel morphogenesis defects in zebrafish embryos. A. Confocal imaging analysis of trunk vascular and somital morphology in WT, maeg−/− and maeg morphants Tg(kdrl:EGFP) embryos at 30 hpf. Red and white square brackets indicate the lumen of the DA and PCV, respectively. DA, dorsal aorta; PCV, posterior cardinal vein; and DLAV, dorsal longitudinal anastomotic vessel. B. The statistics of ISV length in WT, maeg−/− and maeg morphants. One-Way ANOVA; ***,P<0.001. C. The statistics of DA and PCV lumen size at 30 hpf. Error bars indicate stdev.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
EGFP egfl6zf774/zf774 ; s843Tg standard conditions Prim-15 dorsal aorta IHC
Prim-15 intersegmental vessel IHC
Prim-15 posterior cardinal vein IHC
s843Tg standard conditions Prim-15 dorsal aorta IHC
Prim-15 intersegmental vessel IHC
Prim-15 posterior cardinal vein IHC
s843Tg + MO1-egfl6 standard conditions Prim-15 dorsal aorta IHC
Prim-15 intersegmental vessel IHC
Prim-15 posterior cardinal vein IHC
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
egfl6zf774/zf774 ; s843Tg standard conditions Prim-5 intersegmental vessel decreased length, abnormal
Prim-5 sprouting angiogenesis decreased occurrence, abnormal
Prim-15 dorsal longitudinal anastomotic vessel blood vessel morphogenesis decreased occurrence, abnormal
Prim-15 intersegmental vessel decreased length, abnormal
Prim-15 sprouting angiogenesis decreased occurrence, abnormal
s843Tg + MO1-egfl6 standard conditions Prim-5 intersegmental vessel decreased length, abnormal
Prim-5 sprouting angiogenesis decreased occurrence, abnormal
Prim-15 dorsal longitudinal anastomotic vessel blood vessel morphogenesis decreased occurrence, abnormal
Prim-15 intersegmental vessel decreased length, abnormal
Prim-15 sprouting angiogenesis decreased occurrence, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Oncotarget for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Oncotarget