|ZFIN ID: ZDB-FIG-160208-19|
The gpc4 mutant craniofacial phenotype is not enhanced by the loss of wnt5b. (A–B) The length of the symplectic element (see inset) from 5 dpf embryos. (A) Measurements of the symplectics from progeny of a dihybrid cross of gpc4m818 and wnt5bta98. The presence of wnt5bta98 does not enhance the gpc4m818 phenotype, but the double heterozygous mutant is significantly different than wild type. Tests of 14 a priori hypotheses were conducted using a Bonferroni adjusted alpha level of 0.00357 (0.05/11). *p = 0.0015, Mann–Whitney U (df) = 20. **p = 0.0021, Mann–Whiney U (df) = 88. (B) The symplectic cartilage is significantly smaller in gpc4fr6 mutants than the symplectic elements in gpc4m818 mutants. *p = 0.0157, Mann–Whitney U (df) = 22. Abbreviations: sy = symplectic, hm = hyomandibular.
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Reprinted from Mechanisms of Development, 138 Pt 3, Sisson, B.E., Dale, R.M., Mui, S.R., Topczewska, J.M., Topczewski, J., A role of glypican4 and wnt5b in chondrocyte stacking underlying craniofacial cartilage morphogenesis, 279-90, Copyright (2015) with permission from Elsevier. Full text @ Mech. Dev.