FIGURE

Fig. 1

ID

ZDB-FIG-140917-15

Publication

Qin et al., 2014 - Nom1 Mediates Pancreas Development by Regulating Ribosome Biogenesis in Zebrafish

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Fig. 1

dg5 mutant has an endodermal and craniofacial defect.

(A, B) Lateral and (G, H) dorsal views of live Wild Type (WT) sibling and dg5 larvae at 3 dpf. Smaller head and eyes can be seen (arrowhead in A, B). Impaired yolk absorption is apparent in dg5 mutant at 3 dpf (arrows in G, H). (C–F, I–L) All dorsal views, anterior to the left. At 3 dpf, the expression of trypsin (try) is markedly reduced in dg5 mutant (D) as compared to WT group (C). The intestine marker fatty acid binding protein 2 (ifabp) expression reveals that the intestine is thinner in dg5 larvae (E) as compared to WT group (F) at 3.5 dpf. The expression of ceruloplasmin (cp) shows that the liver is smaller in dg5 mutant (H) as compared to WT group (I) at 3 dpf. As compared to control group (K), craniofacial development is abnormal in dg5 larvae (L) by alcian blue staining at 4 dpf.

Expression Data

Genes:	cp fabp2 prss1
Fish:	TU nom1^zf591/zf591
Anatomical Terms:	exocrine pancreas intestine liver
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nom1^zf591/zf591
Observed In:	exocrine pancreas eye head intestine liver pancreas development pharyngeal arch yolk
Stage Range:	Protruding-mouth to Day 4

Phenotype Detail

Acknowledgments

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