FIGURE

Fig. 4

ID

ZDB-FIG-100903-24

Publication

Dutta et al., 2010 - Kctd15 inhibits neural crest formation by attenuating Wnt/β-catenin signaling output

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Fig. 4

Kctd15 inhibits NC induction by antagonizing the Wnt signal. (A,B) Kctd15 suppressed NC-specific marker gene induction by Chrd + Wnt3a, but not by Chrd + β-cat* in Xenopus animal caps. Injected RNAs are indicated at the top; expression of slug, foxd3, sox9 and of odc as control was assayed by RT-PCR. (C) Wnt signaling in HEK293T cells was measured by TOPflash luciferase. Kctd15 moderately inhibited Wnt signaling stimulated by Wnt3a or LiCl but not by β-cat*. AC, uninjected animal caps; -RT, without reverse transcriptase; RLU, relative luciferase units.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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