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ZFIN ID: ZDB-FIG-090710-38
Lunt et al., 2009 - Zebrafish ift57, ift88, and ift172 intraflagellar transport mutants disrupt cilia but do not affect hedgehog signaling. Developmental dynamics : an official publication of the American Association of Anatomists   238(7):1744-1759 Full text @ Dev. Dyn.
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage: Day 5

Fig. 7 Alcian blue staining of jaw and brachial arch structure at 5 dpf. A-C: Wild type embryos raised in DMSO vehicle exhibit normal craniofacial head skeleton. D-L: IFT mutants displayed no reduction or loss of the major head structures and no fusion of the trabeculae. M-O: detourgli1 mutants showed significant narrowing of ethmoid plate (black arrow). P: Embryos treated with 100 μM cyclopamine lack all major head cartilage. The top row shows whole-mount images viewed from the ventral side. The middle row shows flat-mount images of dissected dorsal neurocranium structures. The bottom row shows flat-mounted images of dissected ventral structures to show brachial arches.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
gli1ts269/ts269 standard conditions Day 5 ethmoid cartilage decreased width, abnormal
Day 5 trabecula cranii fused with trabecula cranii, abnormal
ift172hi2211Tg/hi2211Tg standard conditions Day 5 neurocranium morphology, normal
ift57hi3417Tg/hi3417Tg standard conditions Day 5 neurocranium morphology, normal
ift88tz288/tz288 standard conditions Day 5 neurocranium morphology, normal
Acknowledgments:
ZFIN wishes to thank the journal Developmental dynamics : an official publication of the American Association of Anatomists for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Dev. Dyn.