ZFIN ID: ZDB-FISH-150901-6080
Fish name: gli1ts269/ts269
Genotype: gli1ts269/ts269
Targeting Reagent: none

HUMAN DISEASE MODELED by gli1ts269/ts269
No data available
GENE EXPRESSION
Gene expression in gli1ts269/ts269
Expressed Gene Structure Conditions Figures
alcama unspecified standard conditions text only from Ungos et al., 2003
dbx1a spinal cord standard conditions Fig. 3 with image from Guner et al., 2007
dbx2 spinal cord standard conditions Fig. 3 with image from Guner et al., 2007
foxa lateral floor plate, medial floor plate control Fig. 5 with image from Karlstrom et al., 2003
fsta central nervous system, diencephalon, epiphysis (all 7) expand standard conditions Fig. 2 from Bergeron et al., 2008
fstl1b somite standard conditions Fig. 2 from Bergeron et al., 2008
irx3a spinal cord standard conditions Fig. 3 with image from Guner et al., 2007
lhx1a unspecified standard conditions text only from Ungos et al., 2003
lhx3 pars anterior, pars intermedia standard conditions Fig. 3 with image from Devine et al., 2009
lrp4 adaxial cell standard conditions Fig. 8 with image from Wang et al., 2013
myl10 adaxial cell standard conditions Fig. 8 with image from Wang et al., 2013
myod1 adaxial cell, somite standard conditions Fig. 3 with image from Wang et al., 2013
Fig. 8 with image from Karlstrom et al., 2003
nkx2.1 diencephalon, hypothalamus, telencephalon standard conditions Fig. 6 with image from Tyurina et al., 2005
Fig. 9 with image from Karlstrom et al., 2003
nkx2.2a adenohypophyseal placode, brain, central nervous system ventral region (all 10) expand control Fig. 2 with image from Wang et al., 2013
Fig. 3 with image from Devine et al., 2009
text only from Sekimizu et al., 2004
Fig. 1 with imageFig. 5 with imageFig. 8 with image from Karlstrom et al., 2003
nkx2.9 brain, (not) lateral floor plate, neural rod (all 4) expand standard conditions Fig. 2 with image from Guner et al., 2007
Fig. 12 from Xu et al., 2006
nkx6.2 central nervous system standard conditions Fig. 2 with image from Guner et al., 2007
nr5a1a forebrain, interrenal primordium, optic stalk standard conditions Fig. 3 from Bergeron et al., 2008
olig2 forebrain, midbrain, motor neuron (all 5) expand standard conditions Fig. 2 with image from Wang et al., 2013
Fig. 2 with image from Guner et al., 2007
pax3a hindbrain, midbrain, roof plate spinal cord region (all 5) expand standard conditions Fig. 5 from Bergeron et al., 2008
Fig. 3 with image from Guner et al., 2007
pax6a CNS interneuron, (not) floor plate, forebrain (all 10) expand standard conditions Fig. 3 with image from Guner et al., 2007
text only from Sekimizu et al., 2004
Fig. 1 with image from Karlstrom et al., 2003
pax7a (not) roof plate spinal cord region, spinal cord standard conditions Fig. 3 with image from Guner et al., 2007
prdm1a adaxial cell standard conditions Fig. 2 with image from Wang et al., 2013
ptch2 central nervous system ventral region, somite standard conditions Fig. 2 with image from Wang et al., 2013
Fig. 1 with image from Karlstrom et al., 2003
rab3c diencephalon, hindbrain, midbrain (all 5) expand standard conditions Fig. 6 from Bergeron et al., 2008
wt1a pronephros standard conditions Fig. 3 from Bergeron et al., 2008
PHENOTYPE 
Phenotype in gli1ts269/ts269
Phenotype Conditions Figures
abducens motor nucleus absent, abnormal standard conditions Table 1 from Brand et al., 1996
adenohypophyseal placode decreased size, abnormal standard conditions Fig. 3 with image from Devine et al., 2009
adenohypophysis morphogenesis process quality, abnormal standard conditions Fig. 3 with image from Devine et al., 2009
adrenocorticotropic hormone secreting cell decreased amount, abnormal control Fig. 4 with image from Devine et al., 2009
brain quality, abnormal standard conditions Fig. for (ts269) from Phenotype Annotation (1994-2006)
central canal morphology, abnormal standard conditions Table 1 from Brand et al., 1996
central canal quality, abnormal standard conditions Fig. for (ts269) from Phenotype Annotation (1994-2006)
central nervous system has fewer parts of type white matter, abnormal standard conditions Table 1 from Brand et al., 1996
chondrocranium morphology, abnormal standard conditions Table 2 from Piotrowski et al., 1996
corticotropin hormone secreting cell differentiation process quality, abnormal control Fig. 4 with image from Devine et al., 2009
cranial neural crest cell mislocalised ventrally, abnormal standard conditions Table 2 from Piotrowski et al., 1996
ethmoid cartilage decreased width, abnormal standard conditions Fig. 7 with image from Lunt et al., 2009
ethmoid cartilage hypoplastic, abnormal standard conditions Fig. 8 from Brand et al., 1996
eye decreased distance eye, abnormal standard conditions Fig. 2 from Brand et al., 1996
eye mislocalised medially, abnormal standard conditions Fig. 2 from Brand et al., 1996
eye quality, abnormal standard conditions Fig. for (ts269) from Phenotype Annotation (1994-2006)
floor plate decreased size, abnormal standard conditions Fig. 3 from Brand et al., 1996
floor plate quality, abnormal standard conditions Fig. for (ts269) from Phenotype Annotation (1994-2006)
floor plate formation disrupted, abnormal standard conditions Fig. 3 from Brand et al., 1996
nervous system quality, abnormal standard conditions Fig. for (ts269) from Phenotype Annotation (1994-2006)
neural tube quality, abnormal standard conditions Fig. for (ts269) from Phenotype Annotation (1994-2006)
optic chiasm malformed, abnormal standard conditions Fig. 7 from Brand et al., 1996
parachordal cartilage fused with parachordal cartilage, abnormal standard conditions Fig. 8 from Brand et al., 1996
pharyngeal arch 3-7 skeleton morphology, abnormal standard conditions Table 1 from Brand et al., 1996
pharyngeal arch 3-7 skeleton quality, abnormal standard conditions Fig. for (ts269) from Phenotype Annotation (1994-2006)
post-vent region curved, abnormal standard conditions Fig. for (ts269) from Phenotype Annotation (1994-2006)
post-vent region curved ventral, abnormal standard conditions Fig. 1 with image from Schwend et al., 2010
Table 1 from Brand et al., 1996
postoptic commissure aplastic, abnormal standard conditions Table 1 from Karlstrom et al., 1996
prolactin secreting cell decreased amount, abnormal control Fig. 4 with image from Devine et al., 2009
prolactin secreting cell differentiation process quality, abnormal control Fig. 4 with image from Devine et al., 2009
retinal ganglion cell axon displaced to diencephalon, abnormal standard conditions Table 1 from Karlstrom et al., 1996
retinal ganglion cell axon ipsilateral to eye, abnormal standard conditions Table 1 from Karlstrom et al., 1996
retinal ganglion cell axon misrouted, abnormal standard conditions Table 1 from Karlstrom et al., 1996
retinal ganglion cell axon guidance disrupted, abnormal standard conditions Fig. 7 from Brand et al., 1996
retinal ganglion cell axon guidance process quality, abnormal standard conditions Table 1 from Karlstrom et al., 1996
retinal ganglion cell axon guidance quality, abnormal standard conditions Fig. for (ts269) from Phenotype Annotation (1994-2006)
sensory system quality, abnormal standard conditions Fig. for (ts269) from Phenotype Annotation (1994-2006)
somatotropin secreting cell decreased amount, abnormal control Fig. 4 with image from Devine et al., 2009
somatotropin secreting cell differentiation process quality, abnormal control Fig. 4 with image from Devine et al., 2009
somite U-shaped, abnormal standard conditions Fig. 1 with image from Schwend et al., 2010
Fig. 1 with image from Karlstrom et al., 2003
trabecula cranii fused with trabecula cranii, abnormal standard conditions Fig. 7 with image from Lunt et al., 2009
Fig. 8 from Brand et al., 1996
whole organism curved ventral, abnormal standard conditions Fig. 1 with image from Karlstrom et al., 2003
whole organism lethal (sensu genetics), abnormal standard conditions Fig. for (ts269) from Phenotype Annotation (1994-2006)
whole organism shape, abnormal standard conditions Fig. for (ts269) from Phenotype Annotation (1994-2006)
whole organism viability, abnormal standard conditions Table 1 from Brand et al., 1996

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