FIGURE

Fig. 1

ID

ZDB-FIG-050729-1

Publication

Albertson et al., 2005 - Roles for fgf8 signaling in left-right patterning of the visceral organs and craniofacial skeleton

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Fig. 1

fgf8 is required for LR asymmetric development of the viscera and morphogenesis of Kupffer′s vesicle (KV). (A–B) By 7 dpf the gall bladder (gb) and pancreas (p) autofluorescence under UV illumination, providing a simple screen for LR situs defects. (A) Wt larvae typically exhibit normal LR situs positioning (situs solus), with the gall bladder to the right of the midline and the pancreas to the left. (B) Approximately 30% of ace/fgf8 mutants exhibit randomized LR situs positioning, including situs inversus. (C) KV is apparent in wt embryos by the five somate stage (black arrow). (D) KV does not develop in approximately 30% of ace/fgf8 mutants (white arrow where KV should be).

Expression Data

Genes:	fgf8a pitx2 spaw tbxta
Fish:	WT fgf8a^{ti282a/ti282a}
Anatomical Terms:	axial mesoderm floor plate diencephalic region forerunner cell group lateral plate mesoderm margin
Stage Range:	Shield to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 283(2), Albertson, R.C., and Yelick, P.C., Roles for fgf8 signaling in left-right patterning of the visceral organs and craniofacial skeleton, 310-321, Copyright (2005) with permission from Elsevier. Full text @ Dev. Biol.