ZFIN ID: ZDB-GENE-990415-72
Gene Name: fibroblast growth factor 8a
Gene Symbol: fgf8a
Sequence Ontology ID : SO:0000704

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Previous Names: fgf-8, fgf8, ace, acerebellar, cb110 (1), etID309886.13 (1), id:ibd5031, wu:fb73a06

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(Including Attributions)
Location: Chr: 13 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 281 figures from 221 publications
Directly Submitted Expression Data: 4 figures (5 images) from Kudoh et al., 2001 [ibd5031]
  7 figures (100 images) from Thisse et al., 2001 [cb110]
Wild-type Stages, Structures: Cleavage:4-cell (1.0h-1.25h) to Adult (90d-730d, breeding adult)
  anatomical structure, anterior macula, apical ectodermal ridge, apical ectodermal ridge pectoral fin bud (all 161) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fgf8a_unspecified Unspecified Unknown Unknown
la012336Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa2694 Point Mutation Unknown Premature Stop ENU
    ti282a Point Mutation Donor Splice Site of Intron 2 Splice Site, Exon Loss of Exon 2, Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • x15 Point Mutation Unknown Premature Stop ENU
    Targeting reagents: CRISPR1-fgf8a (1), CRISPR2-fgf8a (1), CRISPR3-fgf8a (1), CRISPR4-fgf8a (1), CRISPR5-fgf8a (1) (all 15) expand
    PHENOTYPE
    Data: 61 figures from 39 publications
    Observed in: alar plate midbrain region, anatomical system, anterior cardinal vein, apoptotic process (all 91) expand
    DISEASE ASSOCIATED WITH fgf8a HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    hypogonadotropic hypogonadism 6 with or without anosmia Hypogonadotropic hypogonadism 6 with or without anosmia 612702
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process determination of dorsal identity (more)
    Cellular Component extracellular space (more)
    Molecular Function fibroblast growth factor receptor binding (more)
    GO Terms (all 61)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002209 (1)
  • InterPro:IPR008996 (1)
  • InterPro:IPR028249 (1)
  • PROSITE:PS00247 (1)
  • Pfam:PF00167 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA fgf8a-001 (1) 2238
    fgf8a-002 (1) 600
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIESNo data available
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM fgf8a
    Tg(hsp70l:fgf8a), Tg(nkx2.5:fgf8a-GFP), tg(uas:fgf8a-utrnanos3), Tg1(fgf8a:EGFP), Tg1(fgf8a:GFP) (all 27) expand
    MARKER RELATIONSHIPS
    fgf8aContained in: [BAC] CH211-194I8 (1) (order this)
    fgf8aEncodes: [EST] cb110 (1), fb73a06 (1), ibd5031 (1) (order this)
    [cDNA] MGC:101652 (1) (order this), MGC:192193 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131281 (1) 2146bp
    Genomic GenBank:CR925797 (1) 65727bp
    Select Tool
    Polypeptide UniProtKB:A0A0B5JPZ5 (1) 210aa
    Sequence Clusters UniGene:478 (1)
    Sequence Information (all 35)
    OTHER fgf8a GENE PAGES
  • Alliance (1)
  • Gene:30538 (1)
  • VEGA:OTTDARG00000018834 (1)
  • Ensembl(GRCz10):ENSDARG00000003399 (1)
  • ORTHOLOGY for fgf8a (Chr: 13)
    CITATIONS (476)